Molecular Formula | C21H22Cl2FN5O |
Molar Mass | 450.34 |
Density | 1.47±0.1 g/cm3(Predicted) |
Boling Point | 599.2±50.0 °C(Predicted) |
Appearance | Powder |
pKa | 9.81±0.10(Predicted) |
Storage Condition | -20℃ |
MDL | MFCD22126092 |
Use | (S)-crizotinib, The (S) isomer of crizotinib, is a potent MTH1 (nutt1) inhibitor with an IC50 of 72 nM in a cell-free assay. |
In vitro study | (S)-crizotinib disrupts nucleotide Library homeostasis by inhibiting MTH1, induces an increase in DNA single strand breaks, and activates DNA repair mechanisms in human colon cancer cells. (S)-crizotinib disrupts nucleotide Library homeostasis by inhibiting MTH1, induces an increase in DNA single strand breaks, and activates DNA repair mechanisms in human colon cancer cells. |
In vivo study | In the SW480 colon cancer model,(S)-Crizotinib (50 mg/kg, oral, daily) impairs tumor growth. In the SW480 colon cancer model,(S)-Crizotinib (50 mg/kg, oral, daily) impairs tumor growth. |