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(S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diammine

(S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diamine

CAS: 314771-76-1

Molecular Formula: C18H16ClFN4O2

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(S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diammine - Names and Identifiers

Name (S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diamine
Synonyms Afatinib-1
Intermediates of sunitinib
Afatinib-des(4-dimethylamino-2-en-1-oxo)butyl
(S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diamine
(S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diaMine
7-((S)-tetrahydrofuran-3-yloxy)-4-(3-chloro-4-fluorophenyl)amino-6-aminoquinazoline
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-(Tetrahydrofuran-3-Yloxy) Quinazoline-4,6-Diamine
(S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diammine
N4-(3-Chloro-4-fluorophenyl)-7-[[(3S)-tetrahydro-3-furanyl]oxy]-4,6-quinazolinediamine
6-Amino-4-[(3-chloro-4-fluorophenyl)amino]-7-[[(S)-tetrahydro-3-furanyl]oxy]quinazoline
4,6-Quinazolinediamine, N4-(3-chloro-4-fluorophenyl)-7-[[(3S)-tetrahydro-3-furanyl]oxy]-
4-QuinazolinaMine, N-(3-chloro-4-fluorophenyl)-6-amine-7-[[(3S)-tetrahydro-3-furanyl]oxy]-
CAS 314771-76-1
EINECS 1312995-182-4

(S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diammine - Physico-chemical Properties

Molecular FormulaC18H16ClFN4O2
Molar Mass374.8
Density1.473±0.06 g/cm3 (20 ºC 760 Torr)
Boling Point559.0±50.0 °C(Predicted)
pKa5.89±0.30(Predicted)
Storage ConditionKeep in dark place,Inert atmosphere,Room temperature
SensitiveIrritant
MDLMFCD18642925
UseThis product is for scientific research only and shall not be used for other purposes.

(S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diammine - Reference Information

introduction N4-(3-chloro-4-fluorophenyl)-7-[[(3S)-tetrahydro-3-furyl] oxygen]-4, 6-quinazoline diamine is a light yellow solid, which can be used as a pharmaceutical intermediate for pharmaceutical synthesis and experimental research.
use quinazoline ring is a dominant skeleton structure that can combine with a variety of biological macromolecules to produce different biological activities. In particular, N4-(3-chloro-4-fluorophenyl)-7-[[(3S)-tetrahydro-3-furyl] oxy]-4, 6-quinazoline diamine is particularly prominent as an intermediate in the synthesis of antitumor drugs. It is expected that in the near future, through the overall design and optimization of the quinazoline ring in this molecule to develop high-efficiency and low-toxicity anticancer drugs, there will be breakthrough progress, which will contribute to human life and health.
Last Update：2024-04-09 02:00:01
(S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diammine
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View History
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