(S)-(+)-2-(aminomethyl)pyrrolidine - Names and Identifiers
(S)-(+)-2-(aminomethyl)pyrrolidine - Physico-chemical Properties
Molecular Formula | C5H12N2
|
Molar Mass | 100.16 |
Density | 0.933g/mLat 25°C(lit.) |
Boling Point | 65°C11mm Hg(lit.) |
Flash Point | 117°F |
Vapor Presure | 3.42mmHg at 25°C |
pKa | 10.68±0.10(Predicted) |
Storage Condition | 2-8℃ |
Refractive Index | n20/D 1.482(lit.) |
(S)-(+)-2-(aminomethyl)pyrrolidine - Risk and Safety
Hazard Symbols | Xi - Irritant
|
Risk Codes | R10 - Flammable
R36/37/38 - Irritating to eyes, respiratory system and skin.
|
Safety Description | S16 - Keep away from sources of ignition.
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 - Wear suitable protective clothing.
|
UN IDs | UN 2734 8/PG 2 |
WGK Germany | 3 |
HS Code | 29339900 |
Hazard Class | 8/3 |
Packing Group | II |
(S)-(+)-2-(aminomethyl)pyrrolidine - Introduction
(S)-( )-2-(aminomethyl)pyrrolidine, also known as (S)-( )-2-(aminomethyl)pyrrolidine, is an organic compound. It is a derivative of pyrrolidine with an aminomethyl group. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: The common form is a colorless to light yellow liquid.
-Odor: with a special amine odor.
-Solubility: Soluble in water, alcohols and ether solvents.
Use:
-As a chiral catalyst in organic synthesis, it has excellent catalytic activity and selectivity, and is often used in the synthesis of semi-synthetic drugs.
-In the field of medicine, it can be used as an intermediate for the synthesis of antibiotics, hormones, opioid analgesics, etc.
Preparation Method:
(S)-( )-2-(aminomethyl)pyrrolidine has many preparation methods. The following is a common method:
1. First, pyrrolidine is reacted with ammonia formaldehyde to generate 2-aminomethyl pyrrolidine.
2. Next, 2-aminomethylpyrrolidine is subjected to chiral separation to obtain (S)-2-aminomethylpyrrolidine.
Safety Information:
- (S)-( )-2-(aminomethyl)pyrrolidine are irritating chemicals, avoid contact with skin, eyes and respiratory tract.
-Wear protective gloves, goggles and respiratory protection during operation.
-When storing, keep it in a sealed container, away from fire and oxidizing agents.
In general,(S)-( )-2-(aminomethyl)pyrrolidine is a chiral catalyst and intermediate widely used in the field of organic synthesis and medicine, but safety precautions should be paid attention to during use and storage.
Last Update:2024-04-09 21:01:54