(R)-3-Amino-1,2-propanediol - Names and Identifiers
Name | (R)-3-Amino-1,2-propanediol
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Synonyms | (R)-3-Amino-1,2-propanediol (2R)-3-Aminopropane-1,2-diol (2S)-3-AMINOPROPANE-1,2-DIOL 1,2-PROPANEDIOL, 3-AMINO, (S) 1,2-PROPANEDIOL, 3-AMINO, (R) (R)-(+)-3-AMINO-1,2-PROPANDIOL (R)-(+)-3-AMINO-1,2-PROPANEDIOL (R)-(+)-3-Amino-1,2-propanediol 1,2-Propanediol, 3-amino-, (2R)- 1,2-PROPANEDIOL, 3-AMINO-, (2S)- 1,2-PROPANEDIOL, 3-AMINO-, (2R)-
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CAS | 66211-46-9
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InChI | InChI=1/C3H9NO2/c4-1-3(6)2-5/h3,5-6H,1-2,4H2/t3-/m1/s1 |
(R)-3-Amino-1,2-propanediol - Physico-chemical Properties
Molecular Formula | C3H9NO2
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Molar Mass | 91.11 |
Density | 1.175g/mLat 25°C(lit.) |
Melting Point | 54-56°C |
Boling Point | 117-119°C0.4mm Hg(lit.) |
Specific Rotation(α) | +9°(20/D)(neat) |
Flash Point | >230°F |
Solubility | soluble in Methanol |
Vapor Presure | 0.00116mmHg at 25°C |
Appearance | powder to crystal |
Specific Gravity | 1.175 |
Color | White to Orange to Green |
BRN | 4290608 |
pKa | 12.11±0.35(Predicted) |
Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
Refractive Index | n20/D 1.483(lit.) |
MDL | MFCD00798261 |
Physical and Chemical Properties | Density 1.181 melting point 54-56°C boiling point 267°C flash point 115°C
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(R)-3-Amino-1,2-propanediol - Risk and Safety
Hazard Symbols | C - Corrosive
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Risk Codes | R34 - Causes burns
R22 - Harmful if swallowed
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Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
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UN IDs | UN 3259 8/PG 2 |
WGK Germany | 3 |
FLUKA BRAND F CODES | 10-34 |
HS Code | 29221990 |
Hazard Class | 8 |
Packing Group | Ⅱ |
(R)-3-Amino-1,2-propanediol - Introduction
(R)-3-Amino-1,2-propanediol is an organic compound with the chemical formula C3H9NO2. It is a chiral molecule with the configuration of the Latin letter R. The following is a description of the nature, use, preparation and safety information of (R)-3-Amino-1,2-propanediol:
Nature:
-Appearance: Colorless to slightly yellow solid
-Melting point: about 105-110°C
-Boiling point: about 320-337°C
-Soluble: Soluble in water, also soluble in ethanol and ether solvents
-flammability: flammable, but not easy to burn
Use:
(R)-3-Amino-1,2-propanediol plays an important role in drug synthesis and is often used as a chiral intermediate. It can be used to synthesize a variety of drugs, such as beta blockers, anti-allergic drugs, anti-cancer drugs and inhibitors. In addition, it is also used in the synthesis of polymer materials and other important compounds in organic synthesis.
Preparation Method:
(R)-3-Amino-1,2-propanediol has many preparation methods, one of the commonly used methods is the use of ammonia and (R)-malonic acid distillation synthesis. During the synthesis, a chiral catalyst is used to control the chirality of the product.
Safety Information:
(R)-3-Amino-1,2-propanediol is generally considered to be a relatively safe compound. However, as with any chemical substance, proper handling and safety precautions should be observed. Avoid inhaling its dust, contact with skin and eyes during use. In case of contact, rinse immediately with plenty of water and seek medical help. In addition, it should be stored in a dry, well-ventilated place, and away from flammable materials and oxidants. For detailed safety information, refer to the relevant chemical safety data sheets.
Last Update:2024-04-09 20:52:54