(R)-(+)-THALIDOMIDE
(R)-(+)-Thalidomide
CAS: 2614-06-4
Molecular Formula: C13H10N2O4
(R)-(+)-THALIDOMIDE - Names and Identifiers
(R)-(+)-THALIDOMIDE - Physico-chemical Properties
| Molecular Formula | C13H10N2O4 |
| Molar Mass | 258.23 |
| Density | 1.2944 (rough estimate) |
| Melting Point | 269-271°C |
| Boling Point | 401.48°C (rough estimate) |
| Solubility | DMSO: soluble |
| Appearance | Solid |
| Color | white |
| pKa | 10.70±0.40(Predicted) |
| Storage Condition | -20°C Freezer |
| Refractive Index | 1.5300 (estimate) |
| In vitro study | The transport of the (R)-Thalidomide from the R-imprinted MIP-1 through the donor phase to the receiver phase is much less owing to the stronger retention of the thalidomide in the organic phase. With the affinity of (R)-Thalidomide by the MIP present surface capture, that is more strongly than the other forms. In the case of (R)-Thalidomide, it is found to bind to the selective sites of the MIP more strongly than the other which reflects their different biological entities. The (S)-Thalidomide imprints MIP nanoparticles exerted a greater cytotoxic effect on the caco-2 cells than the (R)-Thalidomide imprinted MIPs. |
| In vivo study | Adult female F344 rats are implanted with 9L gliosarcoma tumours intracranially, subcutaneously (flank), or both. Effectiveness of oral thalidomide alone, and with intraperitoneal BCNU or cisplatin combination chemotherapy, is assessed after several weeks treatment. Both serum and tissue concentrations of (R)-thalidomide are 40-50% greater than those of (S)-thalidomide. Co-administration of BCNU or cisplatin with thalidomide did not alter the concentration enantioselectivity. |
(R)-(+)-THALIDOMIDE - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | R61 - May cause harm to the unborn child R22 - Harmful if swallowed |
| Safety Description | S53 - Avoid exposure - obtain special instructions before use. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| WGK Germany | 3 |
| RTECS | TI4925000 |
(R)-(+)-THALIDOMIDE - Reference Information
| biological activity | (R)-thiidomide ((R)-( )-thiidomide) it is the R-enantiomer of thridomide. (R)-thiidomide has a sedative effect. |
Last Update：2024-04-09 20:02:46
