(6alpha,11beta)-6,9-Difluoro-11,17,21-trihydroxypregna-1,4-diene-3,20-dione - Names and Identifiers
Name | 6α,9-difluoro-11β,17,21-trihydroxypregna-1,4-diene-3,20-dione
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Synonyms | 6a-Fluoro-isoflupredone 6-α-fluoro-isoflupredone 6-α-FLUORO-ISOFLUPREDONE 6α,9α-Difluoroprednisolone 6-alpha-fluoro-isoflupredone 6,9-difluoro-11,17,21-trihydroxypregna-1,4-diene-3,20-dione 6a,9-difluoro-11b,17,21-trihydroxypregna-1,4-diene-3,20-dione 6α,9-difluoro-11β,17,21-trihydroxypregna-1,4-diene-3,20-dione 6alpha,9-difluoro-11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione (6alpha,11beta)-6,9-Difluoro-11,17,21-trihydroxypregna-1,4-diene-3,20-dione pregna-1,4-diene-3,20-dione, 6,9-difluoro-11,17,21-trihydroxy-, (6alpha,11beta)- (6S,8S,9R,10S,11S,13S,14S,17R)-6,9-Difluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
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CAS | 806-29-1
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EINECS | 212-360-8 |
InChI | InChI=1/C21H26F2O5/c1-18-5-3-11(25)7-14(18)15(22)8-13-12-4-6-20(28,17(27)10-24)19(12,2)9-16(26)21(13,18)23/h3,5,7,12-13,15-16,24,26,28H,4,6,8-10H2,1-2H3 |
(6alpha,11beta)-6,9-Difluoro-11,17,21-trihydroxypregna-1,4-diene-3,20-dione - Physico-chemical Properties
Molecular Formula | C21H26F2O5
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Molar Mass | 396.42 |
Density | 1.39±0.1 g/cm3(Predicted) |
Melting Point | 250-257 °C (decomp) |
Boling Point | 568.3±50.0 °C(Predicted) |
Flash Point | 297.5°C |
Solubility | Dioxane (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly) |
Vapor Presure | 2.79E-15mmHg at 25°C |
Appearance | Solid |
Color | White to Pale Beige |
pKa | 11.96±0.70(Predicted) |
Storage Condition | 2-8°C |
Refractive Index | 1.586 |
(6alpha,11beta)-6,9-Difluoro-11,17,21-trihydroxypregna-1,4-diene-3,20-dione - Introduction
6α, 9-difluororo-11β, 17,21-trihydroxyregna-1, 4-diene-3,20-dione, chemical formula C22H28F2O8, is a synthetic potent glucocorticoid. The following is a description of some properties, uses, preparation and safety information about the substance:
Nature:
- 6α, 9-difluororo-11β, 17,21-trihydroxypregna-1,4-diene-3,20-dione is a white crystalline powder.
-It is stable at room temperature and can be dissolved in some organic solvents and water under certain conditions.
-It has anti-inflammatory, anti-allergic and immunosuppressive effects.
Use:
- 6α, 9-difluororo-11β, 17,21-trihydroxypregna-1,4-diene-3,20-dione is mainly used to treat various inflammatory and immune diseases, including asthma, rheumatoid arthritis, skin allergies, adrenal cortex dysfunction, etc.
-It can also be used to replace the defects of natural glucocorticoids, such as adrenal insufficiency.
Preparation Method:
The preparation of-6α, 9-difluororo-11β, 17,21-trihydroxypregna-1,4-diene-3,20-dione is usually carried out by synthetic chemical methods.
-The specific process includes fluorination, isofluorination and hydroxylation of prednisone acetate.
Safety Information:
- 6α, 9-difluororo-11β, 17,21-trihydroxypregna-1,4-diene-3,20-dione In medical use, it is usually used according to the doctor's instructions and dosage to reduce the risk of side effects.
-Long-term and excessive use may cause side effects such as suppression of adrenal cortex function, osteoporosis, suppression of the immune system, and hormone dependence.
-in the use of the process, need to pay attention to observation and control of the dose, can not suddenly stop the drug to avoid withdrawal phenomenon.
-Please use under the guidance of a doctor, follow the relevant instructions for use and pay attention to your personal situation.
Last Update:2024-04-10 22:29:15