(5-氟-2-甲酰基苯基)硼酸
3,5-Difluorobenzyl bromide
CAS: 141776-91-2;1256355-30-2
Molecular Formula: C7H6BFO3
(5-氟-2-甲酰基苯基)硼酸 - Names and Identifiers
| Name | 3,5-Difluorobenzyl bromide |
| Synonyms | FR CF E1E 141776-91-2 3,5-difluorobromobenzyl 3,5-Difluorobenzyl bromide 1-(Brommethyl)-3,5-difluorbenzol 1-(Bromomethyl)-3,5-difluorobenzene 5-Fluoro-2-formylphenylboronic acid 5-Fluoro-2-formylbenzeneboronic acid Benzene, 1-(bromomethyl)-3,5-difluoro- Boronic acid, B-(5-fluoro-2-formylphenyl)- 2,4,4,5,7,7,8,10,10,11,13,13,14,14,15,15,15-heptadecafluoro-2,5,8,11-tetrakis(trifluoromethyl)-3,6,9,12-tetraoxapentadecan-1-ol |
| CAS | 141776-91-2 1256355-30-2 |
| InChI | InChI=1/C15H3F29O5/c16-2(1-45,7(22,23)24)46-13(39,40)4(19,9(28,29)30)48-15(43,44)6(21,11(34,35)36)49-14(41,42)5(20,10(31,32)33)47-12(37,38)3(17,18)8(25,26)27/h45H,1H2 |
(5-氟-2-甲酰基苯基)硼酸 - Physico-chemical Properties
| Molecular Formula | C7H6BFO3 |
| Molar Mass | 167.93 |
| Density | 1.33±0.1 g/cm3(Predicted) |
| Boling Point | 365.2±52.0 °C(Predicted) |
| Flash Point | 173.8°C |
| Vapor Presure | 2.49E-07mmHg at 25°C |
| pKa | 7.15±0.53(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Refractive Index | 1.295 |
| MDL | MFCD09953731 |
(5-氟-2-甲酰基苯基)硼酸 - Risk and Safety
| Hazard Symbols | C - Corrosive |
| Risk Codes | R34 - Causes burns |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 3265 |
(5-氟-2-甲酰基苯基)硼酸 - Introduction
3,5-Difluorobenzyl bromide is an organic compound with the chemical formula C7H5BrF2. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: 3,5-difluorobenzyl bromide is a colorless to pale yellow crystal or liquid.
-Solubility: It is soluble in organic solvents such as ethanol, ether and chloroform at room temperature.
-Melting point: Its melting point is about -10°C to -8°C, and its boiling point is about 75°C to 77°C.
Use:
-Chemical synthesis: 3,5-difluorobenzyl bromide can be used as an important raw material or intermediate in the chemical synthesis process for the preparation of various organic compounds, such as pesticides, medicines and dyes.
Preparation Method:
There are several methods for preparing 3,5-difluorobenzyl bromide, one of which is commonly used by bromination of 3,5-difluorobenzyl alcohol:
1. Dissolve 3,5-difluorobenzyl alcohol in an organic solvent, such as dimethylformamide (DMF) or N,N-dimethylformamide (DMF).
2. Add an appropriate amount of phosphorus tribromide (PBr3) and react at room temperature for a period of time.
3. Distilling off the solvent and unreacted materials to obtain 3,5-difluorobenzyl bromide from the reaction product.
Safety Information:
- 3,5-Difluorobenzyl bromide is an organic compound that is potentially dangerous. In the use or handling, should strictly abide by the safety procedures and personal protective measures.
-Possible hazard to human health by inhalation, contact or ingestion of 3,5-difluorobenzyl bromide. Contact with skin, eyes and respiratory tract should be avoided, and appropriate protective gloves and masks should be worn if necessary.
-When storing and handling the compound, it should be placed in a sealed container, away from high temperature, open flame and oxidizing agent.
-In the event of a leak or accident, immediately take the necessary clean-up measures to avoid spreading.
Please note that before using and handling this compound, it is best to refer to the relevant safety data sheet (SDS) and follow the guidance of professionals.
Nature:
-Appearance: 3,5-difluorobenzyl bromide is a colorless to pale yellow crystal or liquid.
-Solubility: It is soluble in organic solvents such as ethanol, ether and chloroform at room temperature.
-Melting point: Its melting point is about -10°C to -8°C, and its boiling point is about 75°C to 77°C.
Use:
-Chemical synthesis: 3,5-difluorobenzyl bromide can be used as an important raw material or intermediate in the chemical synthesis process for the preparation of various organic compounds, such as pesticides, medicines and dyes.
Preparation Method:
There are several methods for preparing 3,5-difluorobenzyl bromide, one of which is commonly used by bromination of 3,5-difluorobenzyl alcohol:
1. Dissolve 3,5-difluorobenzyl alcohol in an organic solvent, such as dimethylformamide (DMF) or N,N-dimethylformamide (DMF).
2. Add an appropriate amount of phosphorus tribromide (PBr3) and react at room temperature for a period of time.
3. Distilling off the solvent and unreacted materials to obtain 3,5-difluorobenzyl bromide from the reaction product.
Safety Information:
- 3,5-Difluorobenzyl bromide is an organic compound that is potentially dangerous. In the use or handling, should strictly abide by the safety procedures and personal protective measures.
-Possible hazard to human health by inhalation, contact or ingestion of 3,5-difluorobenzyl bromide. Contact with skin, eyes and respiratory tract should be avoided, and appropriate protective gloves and masks should be worn if necessary.
-When storing and handling the compound, it should be placed in a sealed container, away from high temperature, open flame and oxidizing agent.
-In the event of a leak or accident, immediately take the necessary clean-up measures to avoid spreading.
Please note that before using and handling this compound, it is best to refer to the relevant safety data sheet (SDS) and follow the guidance of professionals.
Last Update：2024-04-09 15:17:52
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View History
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