(5-Bromopyridin-3-yl)acetylene - Names and Identifiers
(5-Bromopyridin-3-yl)acetylene - Physico-chemical Properties
Molecular Formula | C7H4BrN
|
Molar Mass | 182.02 |
Density | 1.60±0.1 g/cm3(Predicted) |
Boling Point | 226.1±25.0 °C(Predicted) |
pKa | 1.36±0.20(Predicted) |
Storage Condition | 2-8°C |
(5-Bromopyridin-3-yl)acetylene - Introduction
3-Bromo-5-ethynylpyriridine is an organic compound with the chemical formula C8H5BrN. The following is an introduction to its nature, use, preparation and safety information:
Nature:
-Appearance: colorless or yellowish crystal
-Melting point: 72-73°C
-Boiling Point: 280-285°C
-Density: 1.404g/cm³
-Soluble: Soluble in organic solvents such as ethanol, ether and dichloromethane
Use:
3-Bromo-5-ethynylpyridine has a wide range of applications in the field of organic synthesis, commonly used in the following reactions:
-As a ligand: it can form complexes with transition metals and be used in catalytic reactions.
-Reagent: can participate in a variety of organic reactions, such as nucleophilic substitution, ammonia alkylation reaction.
-Organic material: It can be used to prepare organic materials containing pyridine structure, such as liquid crystal materials and photosensitive materials.
Preparation Method:
3-Bromo-5-ethynylpyriridine can be prepared by the following steps:
1. First, pyridine and butyl lithium are reacted to prepare a pyridoxine metal compound with negative charge.
2. Then, by reacting with 3-bromoacetone, the bromine group is introduced into the pyridine metal compound.
3. Finally, by reacting with sodium acetylene, the ethynyl group is introduced into 3-Bromo-5-ethynylpyridine.
Safety Information:
-3-Bromo-5-ethynylpyriridine may be irritating to the eyes and skin, and protective measures should be taken when using it.
-Avoid contact with oxidants and strong acids during use or storage.
-During operation, keep the room well ventilated and avoid inhalation or skin contact.
-Before use should be carefully read and follow the relevant safety instructions.
In general, 3-Bromo-5-ethynylpyriridine is an organic compound with a wide range of applications, but it is necessary to pay attention to safety and take necessary protective measures when using it.
Last Update:2024-04-10 22:29:15