(4-溴-3-甲基吡唑-5-基)甲醇

(4-溴-3-甲基吡唑-5-基)甲醇 - Names and Identifiers

Name	(4-Bromo-1-methyl-1H-pyrazol-3-yl)methanol
Synonyms	(4-bromo-1-methyl-pyrazol-3-yl)methanol 1H-Pyrazole-3-methanol, 4-bromo-1-methyl- (4-Bromo-1-methyl-1H-pyrazol-3-yl)methanol 4-Bromo-3-(hydroxymethyl)-1-methyl-1H-pyrazole
CAS	915707-65-2

(4-溴-3-甲基吡唑-5-基)甲醇 - Physico-chemical Properties

Molecular Formula	C5H7BrN2O
Molar Mass	191.03
Density	1.75±0.1 g/cm3(Predicted)
Melting Point	94 °C
Boling Point	308.4±27.0 °C(Predicted)
pKa	12.88±0.10(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C

(4-溴-3-甲基吡唑-5-基)甲醇 - Risk and Safety

Hazard Note

Harmful

(4-溴-3-甲基吡唑-5-基)甲醇 - Reference Information

Application

(4-bromo-1-methyl-3-pyrazolyl) Methanol has a simple structure, it is a good intermediate with many active groups, and its derivatives are known to be involved in the fields of medicine, aerospace, functional materials, petroleum processing and the like.

preparation

The reaction system is protected with nitrogen, add 171g of 4-bromo-1-methyl-3-pyrazolyl carboxylate methyl ester into the flask, add 600g of toluene (chlorobenzene, benzene, P-toluene, etc. can also be used), and stir to clarify, the flask was cooled with an ethanol-dry ice bath. When the internal temperature is -10 ℃, 455g of red aluminum (70% of toluene solution) is added dropwise, and the process is exothermic. At the beginning of the reaction system, there is trace water, which leads to the dropwise addition of red aluminum and outgassing, the rate of dropwise addition of red aluminum was controlled so that the temperature did not exceed 0 °c. After the completion of the drop of red aluminum, stir at -10-0 ℃ for 30min, and no raw material (Central Control 1) is sampled and tested. The drop of 350g Saturated sodium carbonate solution is started, and the drop of heat and gas release is intense at the beginning, control the dropping acceleration so that the temperature of the reaction solution does not exceed 20 ° C. After the completion of the dropwise addition of saturated sodium bicarbonate solution, stir for 30min, another layer of turbid liquid with 100g toluene (can also use 150g, 250g, 300g of chlorobenzene, benzene, toluene, etc.) Extraction, after separation and then 100g (can also use 150g, 250g, 300g of chlorobenzene, benzene, toluene, etc.) toluene extraction once, combined organic layer, with 200g (can also use 150g, 250g, 300g) were washed once with water, and then the organic layer was subjected to removal of the solvent (60-70 ° C.) under reduced pressure to obtain 141.3g of (4-bromo-1-methyl-3-pyrazolyl) methanol.

Last Update：2024-04-09 21:04:16