(4-((2-(2,5-Dimethylphenoxy)ethyl)amino)piperidin-1-yl)(pyridin-4-yl)methanone
GRP-60367
CAS: 1309241-34-6
Molecular Formula: C21H27N3O2
(4-((2-(2,5-Dimethylphenoxy)ethyl)amino)piperidin-1-yl)(pyridin-4-yl)methanone - Names and Identifiers
| Name | GRP-60367 |
| Synonyms | GRP-60367 (4-((2-(2,5-Dimethylphenoxy)ethyl)amino)piperidin-1-yl)(pyridin-4-yl)methanone |
| CAS | 1309241-34-6 |
(4-((2-(2,5-Dimethylphenoxy)ethyl)amino)piperidin-1-yl)(pyridin-4-yl)methanone - Physico-chemical Properties
| Molecular Formula | C21H27N3O2 |
| Molar Mass | 353.46 |
| Solubility | Soluble in DMSO |
| Storage Condition | -20℃ |
| Use | GRP-60367 is a potent and selective rabies virus (RABV) entry inhibitor with nanomolar potency against some RABV strains. GRP-60367 inhibits entry of a subset of RABV strains. Resistance profiling of the chemotype revealed hot spots in conserved hydrophobic positions of the RABV G protein fusion loop that were confirmed in transient cell-to-cell fusion assays. Transfer of RABV G genes with signature resistance mutations into a recombinant VSV backbone resulted in the recovery of replication-competent virions with low susceptibility to the inhibitor. |
| In vitro study | GRP-60367 inhibits entry of a subset of RABV strains. GRP-60367 shows specific and potent anti-RABV activity of the scaffold, returning in dose-response assays EC 50 s ranging from 2 to 52 nM on different host cell lines. |
(4-((2-(2,5-Dimethylphenoxy)ethyl)amino)piperidin-1-yl)(pyridin-4-yl)methanone - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.829 ml | 14.146 ml | 28.291 ml |
| 5 mM | 0.566 ml | 2.829 ml | 5.658 ml |
| 10 mM | 0.283 ml | 1.415 ml | 2.829 ml |
| 5 mM | 0.057 ml | 0.283 ml | 0.566 ml |
Last Update：2024-01-02 23:10:35
(4-((2-(2,5-Dimethylphenoxy)ethyl)amino)piperidin-1-yl)(pyridin-4-yl)methanone - Reference Information
| biological activity | GRP-60367 is the first small molecule rabies Virus (RABV) entry inhibitor, it has a nanomolar effect on some RABV strains. |
| Target | RABV |
Last Update：2024-04-09 15:16:56
Supplier List
Spot supply
Product Name: GRP-60367 Visit Supplier Webpage Request for quotationCAS: 1309241-34-6
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: GRP-60367 Visit Supplier Webpage Request for quotationCAS: 1309241-34-6
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: (4-((2-(2,5-Dimethylphenoxy)ethyl)amino)piperidin-1-yl)(pyridin-4-yl)methanone Visit Supplier Webpage Request for quotationCAS: 1309241-34-6
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: GRP-60367 Visit Supplier Webpage Request for quotationCAS: 1309241-34-6
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: GRP-60367 Visit Supplier Webpage Request for quotationCAS: 1309241-34-6
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: (4-((2-(2,5-Dimethylphenoxy)ethyl)amino)piperidin-1-yl)(pyridin-4-yl)methanone Visit Supplier Webpage Request for quotationCAS: 1309241-34-6
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
View History
(4-((2-(2,5-Dimethylphenoxy)ethyl)amino)piperidin-1-yl)(pyridin-4-yl)methanone
CID 80463414
5-甲基-2-硫代尿嘧啶
1239484-03-7
4-IODOPHENYLACETIC ACID
3-甲氧基-4-(3-甲苄基)氧基-苯甲酸
1-(4-bromophenyl)-2,2,2-trifluoroethanone oxime
543910-82-3
艾沙康唑侧链C2
petroleum residues, atmospheric tower
CID 80463414
5-甲基-2-硫代尿嘧啶
1239484-03-7
4-IODOPHENYLACETIC ACID
3-甲氧基-4-(3-甲苄基)氧基-苯甲酸
1-(4-bromophenyl)-2,2,2-trifluoroethanone oxime
543910-82-3
艾沙康唑侧链C2
petroleum residues, atmospheric tower