Name | (3beta,5alpha,6beta,17beta)-cevane-3,6-diol |
Synonyms | Hujiasu Delavine Hupehenine HUPEHENINE Cevane-3,6-diol(3β,5α,6β,17β) (3beta,5alpha,6beta,17beta)-Cevane-3,6-diol (3beta,5alpha,6beta,17beta)-cevane-3,6-diol cevane-3,6-diol, (3beta,5alpha,6beta,17beta)- |
CAS | 98243-57-3 |
InChI | InChI=1/C27H45NO2/c1-15-4-7-25-16(2)18-5-6-19-20(22(18)14-28(25)13-15)11-23-21(19)12-26(30)24-10-17(29)8-9-27(23,24)3/h15-26,29-30H,4-14H2,1-3H3/t15-,16+,17-,18-,19+,20+,21-,22+,23-,24+,25-,26+,27+/m0/s1 |
Molecular Formula | C27H45NO2 |
Molar Mass | 415.65 |
Density | 1.13±0.1 g/cm3(Predicted) |
Melting Point | 181-182 °C |
Boling Point | 538.0±35.0 °C(Predicted) |
Specific Rotation(α) | -20.0°(chloroform) |
Flash Point | 250.376°C |
Solubility | Soluble in acidic solution, insoluble in petroleum ether, chloroform and other solvents. |
Vapor Presure | 0mmHg at 25°C |
Appearance | Colorless crystal |
pKa | 14.80±0.70(Predicted) |
Storage Condition | 2-8℃ |
Refractive Index | 1.577 |
Physical and Chemical Properties | White crystalline powder, soluble in methanol, derived from Fritillaria. |
Safety Description | 24/25 - Avoid contact with skin and eyes. |
HS Code | 29389090 |
Reference Show more | 1. [IF=4.411] Simona S. Ghanem et al."Natural Alkaloid Compounds as Inhibitors for Alpha-Synuclein Seeded Fibril Formation and Toxicity."Molecules. 2021 Jan;26(12):3736 |
Overview | Fritillaria Hubei is the dry bulb of Fritillaria Liliaceae, slightly bitter, cool, into the lung, heart, it has the effect of clearing away heat and moistening lung, resolving phlegm, relieving cough and dispersing knot. In 1991, Fritillaria thunbergii was approved by the Ministry of Chinese herbal medicine standard collection, is now contained in the "People's Republic of China Pharmacopoeia" (2000 edition), developed after Fritillaria thunbergii, the second largest mainstream varieties, with heat-clearing and detoxification, phlegm and cough, is one of the commonly used varieties of traditional Chinese medicine. Mainly produced in Hubei Enshi, Jianshi, Xuanen, Lichuan, Wufeng, Yichang and other counties and cities. |
Use | Fritillaria Hubei is the dry bulb of Fritillaria Liliaceae, slightly bitter, cool, into the lung, heart, it has the effect of clearing away heat and moistening lung, resolving phlegm, relieving cough and dispersing knot. In 1991, Fritillaria thunbergii was approved by the Ministry of Chinese herbal medicine standard collection, is now contained in the "People's Republic of China Pharmacopoeia" (2000 edition), developed after Fritillaria thunbergii, the second largest mainstream varieties, with heat-clearing and detoxification, phlegm and cough, is one of the commonly used varieties of traditional Chinese medicine. lacustrine nail has hypolipidemic effect. for content determination/identification/pharmacological experiments. Pharmacological effects: heat and runfei, phlegm cough. |
biological activity | Hupehenine is an isosteroidal alkaloid with biological activity, which is the main antitussive component in Fritillariae Bulbus. |