Name | N-Methyl-L-tryptophan |
Synonyms | ABRINE L-ABRINE ABRINE, L- H-METRP-OH N-ME-TRP-OH L-(+)-Abrine H-N-Me-Trp-OH N-ME-TRP-OH HCL N-ME-TRYPTOPHAN N-METHYLTRYPTOPHAN N-Methyl-L-tryptophan (2S)-3-(1H-Indol-3-yl)-2-(methylammonio)propanoate |
CAS | 526-31-8 |
EINECS | 208-388-5 |
InChI | InChI=1/C12H14N2O2/c1-13-11(12(15)16)6-8-7-14-10-5-3-2-4-9(8)10/h2-5,7,11,13-14H,6H2,1H3,(H,15,16)/t11-/m0/s1 |
Molecular Formula | C12H14N2O2 |
Molar Mass | 218.25 |
Density | 1.272±0.06 g/cm3 (20 ºC 760 Torr) |
Melting Point | >300°C (dec.)(lit.) |
Boling Point | 358.94°C (rough estimate) |
Specific Rotation(α) | D21 +44° (0.28 g in 10 ml 0.5N HCl) |
Flash Point | 219.4°C |
Vapor Presure | 1.74E-08mmHg at 25°C |
Merck | 14,10 |
BRN | 86638 |
pKa | 2.32±0.10(Predicted) |
Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
Refractive Index | 65 ° (C=1, 0.5mol/L |
In vitro study | L-(+)-Abrine is a marker for abrin poisoning. A strong indication for abrin poisoning is the presence of the chemical maker L-(+)-Abrine, which can survive metabolism in significant amounts making it detectable in human urine. |
In vivo study | Abrin is a toxic protein found in the jequirity seed. L-(+)-Abrine (L-Abrine) is also found in the jequirity seed and can be used as a biomarker for abrin exposure. An animal study is designed to monitor the excretion and recovery of L-(+)-Abrine in 20 rats. The animals are exposed to one of three concentrations of L-(+)-Abrine, a single high concentration of L-tryptophan, or no agent (control). The low L-(+)-Abrine dose corresponds to 0.63 LD 50 i.p. abrin in mice, assuming a concentration ratio of 1:4 of abrin to L-(+)-Abrine and an LD 50 for abrin of 20 μg/kg. The mid and high L-(+)-Abrine (250 and 400 μg/kg) doses are included to ensure that the target analyte can be detected and tracked over the course of the experiment. |
Hazard Symbols | Xn - Harmful |
Risk Codes | 20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
Safety Description | 36 - Wear suitable protective clothing. |
WGK Germany | 3 |
HS Code | 29339900 |