(2-Chloro-5-(trifluoromethoxy)phenyl)boronicacid

(2-Chloro-5-(trifluoromethoxy)phenyl)boronicacid - Names and Identifiers

Name	(2-Chloro-5-(trifluoromethoxy)phenyl)boronicacid
Synonyms	2-CHLORO-5-(TRIFLUOROMETHOXY)PHENYLBORONIC ACID 2-Chloro-5-(Trifluoromethoxy)Phenylboronic Acid 2-CHLORO-5-(TRIFLUOROMETHOXY)BENZENEBORONIC ACID (2-Chloro-5-(trifluoromethoxy)phenyl)boronicacid Boronic acid, B-[2-chloro-5-(trifluoromethoxy)phenyl]-
CAS	1022922-16-2

(2-Chloro-5-(trifluoromethoxy)phenyl)boronicacid - Physico-chemical Properties

Molecular Formula	C7H5BClF3O3
Molar Mass	240.37
Density	1.53±0.1 g/cm3(Predicted)
Boling Point	303.9±52.0 °C(Predicted)
Appearance	Solid
pKa	7.09±0.58(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C

(2-Chloro-5-(trifluoromethoxy)phenyl)boronicacid - Risk and Safety

Risk Codes	25 - Toxic if swallowed
Safety Description	45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
UN IDs	UN 2811 6.1 / PGIII
HS Code	29319090
Hazard Class	IRRITANT

(2-Chloro-5-(trifluoromethoxy)phenyl)boronicacid - Introduction

2-Chloro-5-trifluoromethoxybenzene boronic acid, chemical formula C7H4ClBF3O2, is an organic boron compound. The following is a description of its nature, use, preparation and safety information:

Nature:
-Appearance: 2-chloro-5-trifluoromethoxybenzeneboronic acid is a white to light yellow solid.
-Melting point: about 140-150 degrees Celsius.
-Solubility: Soluble in organic solvents such as chlorinated methane and dichloromethane, slightly soluble in water.
-Molecular structure: Its molecule contains a benzene ring, in which a chlorine atom and a trifluoromethoxy group are respectively connected to the 2nd and 5th positions.

Use:
-2-Chloro-5-trifluoromethoxybenzeneboronic acid is an important intermediate in the field of organic synthesis and can be used to synthesize other compounds, such as drugs and pesticides.
-It can also be used as a ligand to form a complex with transition metal ions for catalytic reactions.

Preparation Method:
The preparation of-2-chloro-5-trifluoromethoxybenzene boronic acid is usually achieved by chlorination and electrophilic substitution of trifluoromethylphenol.
-First, trifluoromethylphenol is reacted with an electrophile such as thionyl chloride to generate 2-chloro-5-trifluoromethoxybenzene. The reaction is usually carried out at room temperature.
-Then, the obtained 2-chloro-5-trifluoromethoxybenzene is reacted with boric acid to generate the final 2-chloro-5-trifluoromethoxybenzene boronic acid.

Safety Information:
The safety of-2-chloro-5-trifluoromethoxybenzene boronic acid is relatively stable under general use conditions.
-During handling and storage, it is necessary to take appropriate protective measures to avoid direct contact with skin and eyes.
-In industrial production and laboratory operations should comply with the relevant safety procedures and the use of safety equipment.

Last Update：2024-04-09 21:01:54