(2,3-Dioxo-7-(1H-imidazol-1-yl)-6-nitro-1,2,3,4-tetrahydro-1-quinoxalinyl)acetic acid monohydrate
ZONAMPANEL
CAS: 210245-80-0
Molecular Formula: C13H9N5O6
(2,3-Dioxo-7-(1H-imidazol-1-yl)-6-nitro-1,2,3,4-tetrahydro-1-quinoxalinyl)acetic acid monohydrate - Names and Identifiers
(2,3-Dioxo-7-(1H-imidazol-1-yl)-6-nitro-1,2,3,4-tetrahydro-1-quinoxalinyl)acetic acid monohydrate - Physico-chemical Properties
| Molecular Formula | C13H9N5O6 |
| Molar Mass | 331.24 |
| Density | 1.82±0.1 g/cm3(Predicted) |
| pKa | 3.20±0.10(Predicted) |
| In vitro study | Zonampanel inhibits the human MRP4-mediated transport of [ 3 H]oestradiol 17-D-glucuronide in a concentration-dependent manner. In contrast, Zonampanel (up to 1000 mM) does not inhibit the human MRP2- or BCRP-mediated transport of [ 3 H]oestradiol 17-D-glucuronide or [ 3 H]methotrexate. Zonampanel inhibits the uptake of typical substrates by Oat1, Oat2, and Oat3 with inhibition constant (K i ) values of 7.02 to 10.4 μM. A time- and saturable concentration-dependent increase in [ 14 C]Zonampanel uptake is observed in these cells [K m values: 13.4 to 53.6 μM]. |
| In vivo study | In in vivo experiments, probenecid and cimetidine decrease intrinsic clearance for both the renal secretion and biliary excretion of Zonampanel. |
(2,3-Dioxo-7-(1H-imidazol-1-yl)-6-nitro-1,2,3,4-tetrahydro-1-quinoxalinyl)acetic acid monohydrate - References
| biological activity | Zonampanel (YM 872) is a selective AMPA receptor antagonist. |
Last Update：2024-04-09 21:04:16
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(2,3-Dioxo-7-(1H-imidazol-1-yl)-6-nitro-1,2,3,4-tetrahydro-1-quinoxalinyl)acetic acid monohydrate
[2-(cyclohexyloxy)-4-methylphenyl]methanamine
2-Bromo-3,3-dimethyl-N-(2,4-dimethylpent-3-yl)butyramide
tert-butyl 3,3-dimethyl-4-oxopiperidine-1-carboxylate
3-(2-(trifluoromethyl)pyridin-4-yl)-1H-indazol-5-amine
880806-66-6
13852-33-0
50827-54-8
4-BROMO-2,3-DIMETHYLPHENOL
5-Methoxy-7-(3,3-dimethylallyloxy)coumarin
[2-(cyclohexyloxy)-4-methylphenyl]methanamine
2-Bromo-3,3-dimethyl-N-(2,4-dimethylpent-3-yl)butyramide
tert-butyl 3,3-dimethyl-4-oxopiperidine-1-carboxylate
3-(2-(trifluoromethyl)pyridin-4-yl)-1H-indazol-5-amine
880806-66-6
13852-33-0
50827-54-8
4-BROMO-2,3-DIMETHYLPHENOL
5-Methoxy-7-(3,3-dimethylallyloxy)coumarin