Molecular Formula | C12H19F6N4O4P |
Molar Mass | 428.2678402 |
Melting Point | ca 160℃ |
Solubility | Soluble in DMF 1mmol in 2mL. |
Appearance | Powder or Solid |
Color | White to pale yellow |
Storage Condition | Store at -15°C to -25°C. |
Sensitive | Air & Moisture Sensitive |
Hazard Symbols | Xi - Irritant![]() |
Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
WGK Germany | 3 |
HS Code | 2934 99 90 |
Use | (ethyl 2-oxime-cyanoacetate)-N,N-dimethyl-morpholino urea hexafluorophosphate, also known as COMU, is a polypeptide condensation reagent, which is mainly used in the synthesis of polypeptide drug molecules and is widely used in solid phase and liquid phase. compared with the traditional first-generation condensation reagents (carbodiimides) represented by DCC and the second-generation condensation reagents (onium salts) represented by HATU, COMU has better solubility, stability, reactivity, low risk and low sensitivity to the human body; At the same time, the by-products generated are easily soluble in water and can be removed well, so the synthesis of COMU polypeptide drug molecules, especially in the solid phase synthesis of more obvious advantages. |