Molecular Formula | C10H11NO4 |
Molar Mass | 209.2 |
Solubility | 0.1 M NaOH: 15mg/mL |
Appearance | solid |
Color | White to off-white |
Storage Condition | Store at RT |
In vitro study | (S)-MCPG (100 μM) has no detectable effects on basal spine formation or elimination mechanisms in WT slice cultures. (S)-MCPG prevents the increase in spine turnover triggered by TBS and interferes with the mechanisms of activity-dependent spine stabilization in Hippocampal slice cultures. |
Safety Description | 24/25 - Avoid contact with skin and eyes. |
WGK Germany | 3 |
HS Code | 29224985 |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 4.78 ml | 23.901 ml | 47.801 ml |
5 mM | 0.956 ml | 4.78 ml | 9.56 ml |
10 mM | 0.478 ml | 2.39 ml | 4.78 ml |
5 mM | 0.096 ml | 0.478 ml | 0.956 ml |
biological activity | (S)-MCPG (( )-MCPG) it is a potent class I/II metabotropic glutamate receptor (mGluRs) antagonist and is the active isomer of (RS)-MCPG (HY-100371). (S)-MCPG can be used to study the role of mGluRs in spatial learning. |
Animal Model: | Male Lister-Hooded rats in the learning of the Morris water maze |
Dosage: | 20 μg |
Administration: | Intraventricular injection; 20 μg; 4 days |
Result: | Impaired the performance of rats in the spatial version of the Morris water maze, but 1/10 of this dose did not. |