| effect | menadione sodium sulfate is a naphthoquinone-type compound, which is a water-soluble derivative of menadione, it can be used to modulate protein (e. G., tau) aggregation associated with neurodegenerative diseases (e. G., Alzheimer's disease). |
| Introduction | menyl hydroquinone sodium sulfate is a synthetic product of vitamin K3, which is converted into menadione (vitamin K3) in vivo.. It is the same as naturally occurring vitamin K, which is an essential substance for the synthesis of prothrombin (Factor II) by the liver and is also involved in the synthesis of Factor VII, factor IX and Factor X. |
| deficiency | due to factors that limit the absorption or synthesis of vitamin K, such as obstructive jaundice, biliary fistula, chronic diarrhea, ulcerative colitis, regional enteritis, abdominal inflammation, gastrointestinal surgery, gallbladder fibrosis and antibiotic treatment caused by low prothrombin; Due to taking coumarins, salicylates, quinine, quinidine and other causes of prothrombin is too low; For cholelithiasis, biliary ascariasis caused by biliary colic; Can also be used for the detection of liver function. |
| preparation | Cool the mixture of methylene chloride and phosphorus oxychloride to -5 °c, the volume ratio of dichloromethane to phosphorus oxychloride is 10 ∶ 3. Under stirring, the mixture of B, triethylamine and dichloromethane is added dropwise at the same time, and its dosage is 0.1g/mL of B, 0.5g/mL of triethylamine, 2 times the volume of methylene chloride; Temperature control at -5 ℃ ~ 5 ℃, after the drop is completed, continue to stir for 10 minutes, add 5 times the volume of hydrochloric acid aqueous solution of pH 3 washing, liquid separation, water layer with dichloromethane extraction, discard the organic layer, water layer with isobutanol extraction, combined isobutanol layer, dry and concentrated, add petroleum ether, solid C was obtained by filtration after precipitation of solid; Product D was dissolved in 3 times the weight of water, saturated sodium carbonate solution was added dropwise under stirring, to pH 7, and 3 times the volume of acetone was added, when the solid is no longer precipitated, filter, dissolve the filter cake with methanol, filter and dry with anhydrous sodium sulfate, After distilling off the methanol, the solid was recrystallized from acetone-water (volume ratio of acetone to water 3:7) to obtain the product sodium menaphthalene hydroquinone sulfate. The yield of menadione hydroquinone sodium sulfate was 90.0 and the purity was 99.1. According to the common method in pharmaceutics, magnesium stearate was added and compressed into tablets, and the content of sodium menyl hydroquinone sulfate was 5mg/tablet. |
