伊班膦酸钠单水合物
Ibandronate sodium monohydrate
CAS: 138926-19-9
Molecular Formula: C9H24NNaO8P2
伊班膦酸钠单水合物 - Names and Identifiers
| Name | Ibandronate sodium monohydrate |
| Synonyms | Boniva Bonviva Ibandrate BM-21.0955 Ibadronate SodiuM Ibandromate Monosodium Ibandronate sodium monohydrate [1-Hydroxy-3-(methylpentylamino)-propylidene]bisphosphonic acid sodium salt [1-Hydroxy-3-(methylpentylamino)-propylidene]bisphosphonic acid sodium salt monohydrate sodium hydrogen {1-hydroxy-3-[methyl(pentyl)amino]-1-phosphonopropyl}phosphonate hydrate Sodium Trihydrogen (1-Hydroxy-3-(methylpenthylamino)propylidene)diphosphonate Monohydrate |
| CAS | 138926-19-9 |
| EINECS | 639-757-2 |
| InChI | InChI=1/C9H23NO7P2.Na.H2O/c1-3-4-5-7-10(2)8-6-9(11,18(12,13)14)19(15,16)17;;/h11H,3-8H2,1-2H3,(H2,12,13,14)(H2,15,16,17);;1H2/q;+1;/p-1 |
伊班膦酸钠单水合物 - Physico-chemical Properties
| Molecular Formula | C9H24NNaO8P2 |
| Molar Mass | 359.23 |
| Melting Point | 840C (dec) |
| Boling Point | 587.8°C at 760 mmHg |
| Flash Point | 309.3°C |
| Solubility | Soluble in water (72 mg/ml at 25 °C), ethanol (<1 mg/ml at 25 °C), and DMSO (<1 mg/ |
| Vapor Presure | 2.88E-16mmHg at 25°C |
| Appearance | White crystalline powder |
| Color | White |
| Storage Condition | Keep in dark place,Inert atmosphere,2-8°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| Sensitive | Sensitive to light |
| Physical and Chemical Properties | White crystalline powder, soluble in water, insoluble in alcohol. |
| Use | For the treatment of malignant hypercalcemia |
| In vitro study | Ibronate (1.25-2 μm) significantly reduced endothelial cell growth, while ibronate (2 μm) also significantly reduced capillary-like lumen formation and increased endothelial cell apoptosis. Ibandronate (< 100 μm) dose-dependently increased VEGF expression in endothelial cells. Ibandronate (<100 μm) dose-dependently inhibited the growth of prostate cancer cell lines (LNCaP and PC-3). |
| In vivo study | In women with osteoporosis treated for 3 years, Ibandronate is administered daily (2.5 mg) or intermittently (20 mg every other day for 12 doses every 3 months) significantly reduced the risk of new-form vertebral fractures by 62% and 50% (p = 0.0006), respectively. In women with osteoporosis treated for 3 years, Ibandronate is administered daily (2.5 mg) or intermittently (20 mg every other day for 12 doses every 3 months) significantly and progressively increased lumbar BMD by 6.5 and 5.7%, respectively. Ibandronate (< 125 mg/kg s.c.) caused a dose-dependent increase in bone density, cancellous bone volume, and trabecular bone number, failure load (Fmax), and yield load in long bones and vertebrae of ovariectomized rats, and the increased trabecular separation in ovariectomized rats could be completely prevented by any dose of Ibandronate. |
伊班膦酸钠单水合物 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 40 - Limited evidence of a carcinogenic effect |
| Safety Description | S22 - Do not breathe dust. S36 - Wear suitable protective clothing. S24/25 - Avoid contact with skin and eyes. |
| HS Code | 29319090 |
伊班膦酸钠单水合物 - Reference Information
| biological activity | Ibandronate (BM-21.0955, BM-210955, RPR-102289A) is an efficient nitrogen-containing bisphosphonate used to treat osteoporosis. |
| use | for the treatment of malignant hypercalcemia Inhibits bone resorption as a sodium salt and complexed with technetium Tc 99m for bone imaging. The monophosphonates are not active. Biphosphonates are used in disorders affecting the skeleton such a s asteoporosis, metastatic disease, and Paget holmium disease. |
Last Update：2024-04-10 22:29:15
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View History
伊班膦酸钠单水合物
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(氯甲基)三苯基氯化磷
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4-氯-3-三氟甲基苯磺酰氯
1-(2-吡啶基)环丁醇
2-甲基-3-氨基异烟酸甲酯
一氧化氮NO荧光探针DAF-FM
三硫代碳酸钠(硫基酸钠)
N-[(9H-芴-9-基甲氧基)羰基]-D-天冬氨酸4-叔丁酯
(氯甲基)三苯基氯化磷
2-氧代-1,2-二氢螺[吲哚-3,3'-吡咯烷]-1'-羧酸叔丁酯
叔-丁基 3-氧亚基-1,8-二氧杂-4,11-二氮杂螺[5.6]十二烷-11-甲酸基酯