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256376-24-6

BAY 41-2272

CAS: 256376-24-6

Molecular Formula: C20H17FN6

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256376-24-6 - Names and Identifiers

Name BAY 41-2272
Synonyms IN1523
IN1523
BAY 41-2272
256376-24-6
BAY-41-2272
4-B]PYRIDINE
UNII-34A162J6WB
UNII-34A162J6WB
3-(4-Amino-5-cyclopropylpyrimidin-2-yl)-1-(2-fluorobenzyl)-1H-pyrazolo[3
3-(4-AMINO-5-CYCLOPROPYLPYRIMIDIN-2-YL)-1-(2-FLUOROBENZYL)-1H-PYRAZOLO[3
5-Cyclopropyl-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-amine
5-Cyclopropyl-2-[1-[(2-fluorophenyl)Methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-4-pyriMidinaMine
4-Pyrimidinamine, 5-cyclopropyl-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-
CAS 256376-24-6

256376-24-6 - Physico-chemical Properties

Molecular FormulaC20H17FN6
Molar Mass360.39
Density1.49±0.1 g/cm3(Predicted)
Melting Point210.5-211.4°C
Boling Point496.1±45.0 °C(Predicted)
Solubility DMSO: 26mg/mL at60°C
Appearancesolid
Colorwhite
pKa2.71±0.10(Predicted)
Storage ConditionKeep in dark place,Inert atmosphere,2-8°C
In vitro studyIn Vitro, BAY 41-2272 caused concentration-dependent relaxation of human and rabbit cavernous bodies with EC50 of 489.1 nM and 406.3 nM, respectively.
In vivo studyIn female spontaneously hypertensive rats, BAY 41-2272 (10 mg/kg, p.o.) exhibited an antiplatelet effect, greatly reduced blood pressure, and increased survival. In mice infected with C. Albicans, BAY 41-2272 (10 mg/kg, I. p.) not only increases macrophage function, but also significantly increases macrophage-dependent cell influx into the peritoneum, reducing mortality. In db/db-/- II diabetic and obese mice, BAY 41-2272 improved relaxation of the damaged corpus cavernosum (CC).

256376-24-6 - Risk and Safety

Hazard SymbolsXi - Irritant
Irritant
Risk Codes36/37/38 - Irritating to eyes, respiratory system and skin.
Safety DescriptionS26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 - Wear suitable protective clothing.
WGK Germany3

256376-24-6 - Preparation solution concentration reference

 1mg5mg10mg
1 mM2.775 ml13.874 ml27.748 ml
5 mM0.555 ml2.775 ml5.55 ml
10 mM0.277 ml1.387 ml2.775 ml
5 mM0.055 ml0.277 ml0.555 ml
Last Update:2024-01-02 23:10:35
256376-24-6
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Shanghai Macklin Biochemical Co., Ltd
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Shanghai Macklin Biochemical Co., Ltd
Featured ProductsSpot supply
Product Name: BAY 41-2272 Visit Supplier Webpage Request for quotation
CAS: 256376-24-6
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328 Click to send a QQ message
WhatsApp: +86-18821248368
MedChemExpress (MCE)
Spot supply
Product Name: BAY 41-2272 Visit Supplier Webpage Request for quotation
CAS: 256376-24-6
Tel: 609-228-6898
Email: sales@medchemexpress.com
     tech@medchemexpress.com
Mobile: 609-228-6898
SHANGHAI ACMEC BIOCHEMICAL TECHNOLOGY CO., LTD.
Spot supply
Product Name: BAY 41-2272 Visit Supplier Webpage Request for quotation
CAS: 256376-24-6
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922 Click to send a QQ message
Wechat: 18621343501
WhatsApp: +86-18621343501
Shanghai Yuanye Bio-Technology Co., Ltd.
Product Name: BAY 41-2272 Visit Supplier Webpage Request for quotation
CAS: 256376-24-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
View History
256376-24-6
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