中文名 | 蛋白酶体抑制剂 |
英文名 | LACTACYSTIN |
别名 | 乳胞素 蛋白酶体抑制剂 蛋白酶体抑制剂 5级 |
英文别名 | LACTACYSTIN (+)-LACTACYSTIN LACTACYSTIN (NATIVE) LACTACYSTIN, SYNTHETIC LACTACYSTIN, STREPTOMYCES SP 3S-HYDROXY-2R-(1-HYDROXY-2-METHYLPROPYL)-4R-METHYL-5-OXO-2-PYRROLIDINECARBOXYLATE-N-ACETYL-L-CYSTEINE N-ACETYL-S-[(2R,3S,4R)-3-HYDROXY-2-[(1S)-1-HYDROXY-2-METHYLPROPYL]-4-METHYL-5-OXO-2-PYRROLIDINECARBONYL]-L-CYSTEINE (2R,3S,4R)-3-HYDROXY-2-[(1S)-1-HYDROXY-2-METHYLPROPYL]-4-METHYL-5-OXO-2-PYRROLIDINECARBOXY-N-ACETYL-L-CYSTEINE THIOESTER |
CAS | 133343-34-7 |
EINECS | 200-258-5 |
化学式 | C15H24N2O7S |
分子量 | 376.43 |
密度 | 1.367±0.06 g/cm3(Predicted) |
熔点 | 233-235°C dec. |
沸点 | 714.9±60.0 °C(Predicted) |
溶解度 | 溶于DMSO (高达20 mg/ml),水 (高达10 mg/ml) 或乙醇 (高达1 mg/ml)。 |
酸度系数 | 3.11±0.10(Predicted) |
存储条件 | -20°C |
稳定性 | 从提供的购买之日起稳定2年。在DMSO或乙醇中的溶液可以在-20 ° 储存长达1个月。水溶液不稳定,必须在一个工作日内使用。 |
外观 | 粉末 |
颜色 | White to off-white |
体内研究 | Lactacystin (microinjection; 2 µg) induces a Parkinson’s disease-like motor phenotype 5-7 days after injection in young and adult mice. Animal Model: Male C57Bl/6RccHsd mice with 8-9 weeks (young) and 12-14 months (adult) old Dosage: 2 µg Administration: Microinjection Result: Induced a Parkinson’s disease-like motor phenotype 5-7 days after injection in young and adult mice. |
WGK Germany | 3 |
参考资料 展开查看 | 1. [IF=10.392] Haoran Wei et al."KDELR2 promotes breast cancer proliferation via HDAC3-mediated cell cycle progression."Cancer Commun. 2021 Sep;41(9):904-920 |
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