中文名 | 茚托利辛 |
英文名 | Intoplicine |
别名 | 茚托利辛 化合物 T15586 |
英文别名 | Intoplicine 11-(3-Dimethylaminopropylamino)-3-hydroxy-8-methyl-7H-benzo[e]pyrido[4,3-b]indole 7H-Benzo[e]pyrido[4,3-b]indol-3-ol, 11-[[3-(dimethylamino)propyl]amino]-8-methyl- |
CAS | 125974-72-3 |
化学式 | C21H24N4O |
分子量 | 348.44 |
密度 | 1.286±0.06 g/cm3(Predicted) |
熔点 | 216-218 °C |
沸点 | 635.5±55.0 °C(Predicted) |
酸度系数 | 8.26±0.30(Predicted) |
存储条件 | Room Temprature |
体外研究 | Activity of Intoplicine (RP60475), a new DNA topoisomerase I and II inhibitor, against human tumor colony-forming units in vitro. Intoplicine (RP60475) is the most active analogue evaluated in the 7H-benzo[e]-pyrido-[4,3-b]-indole series of antineoplastic compounds. Intoplicine exerts its activity through inhibition of DNA topoisomerase I and II. Intoplicine is found to unwind DNA and to inhibit purified calf thymus topoisomerase II via a stabilization of the ternary cleavable complex. |
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