中文名 | 甲基莲心碱 |
英文名 | Neferine |
别名 | 荷花碱 甲基莲心碱 甲基莲心碱对照品, 甲基莲心碱(标准品) NEFERINE 甲基莲心碱 NEFERINE 甲基莲心碱 标准品 |
英文别名 | Neferin NEFERINE Neferine Methylliensinine 4''-O-Methylliensinine 4-[[(1R)-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-yl]methyl]-2-[[(1R)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl]oxy]phenol 4-[(1,2,3,4-Tetrahydro-6,7-dimethoxy-2-methylisoquinolin-1-yl)methyl]-2-[[1,2,3,4-tetrahydro-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methylisoquinolin-7-yl]oxy]phenol 4-{[(1R)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}-2-{[(1R)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl]oxy}phenol 4-[[(1R)-6,7-Dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-yl]methyl]-2-[[(1R)-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl]oxy]phenol 4-[[(1S)-1,2,3,4-Tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl]methyl]-2-[[(1R)-1,2,3,4-tetrahydro-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-7-isoquinolinyl]oxy]-phenol Phenol,4-[[(1S)-1,2,3,4-tetrahydro-6,7-diMethoxy-2-Methyl-1-isoquinolinyl]Methyl]-2-[[(1R)-1,2,3,4-tetrahydro-6-Methoxy-1-[(4-Methoxyphenyl)Methyl]-2-Methyl-7-isoquinolinyl]oxy]- |
CAS | 2292-16-2 |
化学式 | C38H44N2O6 |
分子量 | 624.77 |
InChI | InChI=1/C38H44N2O6/c1-39-15-14-27-21-36(44-5)38(23-30(27)31(39)17-24-7-10-28(42-3)11-8-24)46-34-19-25(9-12-33(34)41)18-32-29-22-37(45-6)35(43-4)20-26(29)13-16-40(32)2/h7-12,19-23,31-32,41H,13-18H2,1-6H3/t31-,32-/m1/s1 |
InChIKey | MIBATSHDJRIUJK-ROJLCIKYSA-N |
密度 | 1.185±0.06 g/cm3(Predicted) |
熔点 | 59-61 °C |
沸点 | 710.9±60.0 °C(Predicted) |
比旋光度 | -44.1°(c=0.301,chloroform) |
闪点 | 383.8°C |
蒸汽压 | 6.97E-21mmHg at 25°C |
溶解度 | DMSO: >15 mg/mL |
折射率 | 1.601 |
酸度系数 | 9.28±0.45(Predicted) |
存储条件 | 2-8°C |
外观 | 粉末 |
颜色 | white to beige |
物化性质 | 来源于睡莲科植物成熟中的绿色胚芽中提取 |
MDL号 | MFCD01707128 |
WGK Germany | 3 |
RTECS | SM9495000 |
参考资料 展开查看 | 1. 魏萍,薛春苗,潘霖,雷珍珍,曹俊岭.甲基莲心碱对胰岛素抵抗的HepG2细胞降糖的影响[J].临床和实验医学杂志,2020,19(12):1283-1286. 2. 赵文芳, 李慧, 潘思轶,等. 膜组合方式对莲子心水提物中活性成分分离的影响[J]. 中国食品学报, 2017, 17(008):165-169. 3. 隋月, 贺晓双, 王嗣岑. 莲子心中3种主要生物碱含量测定及提取优化[J]. 中国药学杂志, 2018, 53(22):22-28. 4. Tu, Yixuan, Shoulei Yan, and Jie Li. "Impact of harvesting time on the chemical composition and quality of fresh lotus seeds." Horticulture, Environment, and Biotechnology 61.4 (2020): 735-744. 5. [IF=5.279] Xianbao Deng et al."Analysis of Isoquinoline Alkaloid Composition and Wound-Induced Variation in Nelumbo Using HPLC-MS/MS."J Agr Food Chem. 2016;64(5):1130–1136 6. [IF=4.225] Zhao Ping et al."Neferine Promotes GLUT4 Expression and Fusion With the Plasma Membrane to Induce Glucose Uptake in L6 Cells."Front Pharmacol. 2019 Sep;0:999 7. [IF=3.391] Yi Zhong et al."Neferine suppresses vascular endothelial inflammation by inhibiting the NF-κB signaling pathway."Arch Biochem Biophys. 2020 Dec;696:108595 8. [IF=3.373] Na Zhang et al."TLC–MS identification of alkaloids in Leonuri Herba and Leonuri Fructus aided by a newly developed universal derivatisation reagent optimised by the response surface method."Phytochem Analysis. 2021 May;32(3):242-251 9. [IF=3] Qu Lala et al."Phenotypic assessment and ligand screening of ETA/ETB receptors with label-free dynamic mass redistribution assay."N-S Arch Pharmacol. 2020 Jun;393(6):937-950 10. [IF=2.753] Nabila Jahan et al."Neferine improves oxidative stress and apoptosis in benign prostate hyperplasia via Nrf2-ARE pathway.."Redox Rep. 2021;26(1):1-9 11. [IF=1.842] Tu Yixuan et al."Impact of harvesting time on the chemical composition and quality of fresh lotus seeds."Hortic Environ Biote. 2020 Aug;61(4):735-744 12. [IF=5.165] Juanning Ren et al."Qualitative and quantitative analysis of multi-components in Xing-Su-Ning Capsules for quality improvement."Arab J Chem. 2022 Jun;15:103825 |