中文名 | 甘氨鹅脱氧胆酸 |
英文名 | Glycochenodeoxycholic Acid |
别名 | 甘鹅去氧胆酸 甘氨鹅脱氧胆酸 甘氨鹅去氧胆酸 甘氨鹅脱氧胆酸-[D9] 3ALPHA,7ALPHA-二羟基-N-(羧甲基)-5BETA-胆烷-24-酰胺 |
英文别名 | GCDC Glycochenodeoxycholate Chenodeoxycholylglycine Glycochenodeoxycholic Acid N-[(3a,5b,7a)-3,7-dihydroxy-24-oxocholan-24-yl]-Glycine 2-[[(4R)-4-[(3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]acetic acid |
CAS | 640-79-9 |
化学式 | C26H43NO5 |
分子量 | 449.62 |
密度 | 1.162±0.06 g/cm3(Predicted) |
沸点 | 655.6±40.0 °C(Predicted) |
溶解度 | 几乎不溶 (0.016 g/L) (25 ºC) |
酸度系数 | 3.58±0.10(Predicted) |
存储条件 | 2-8℃ |
外观 | 粉末 |
物化性质 | 生物活性 Glycochenodeoxycholic acid是由鹅去氧胆酸盐和甘氨酸在肝脏中形成的胆汁盐。它是一种去垢剂,能溶解脂肪,促进吸收。 |
MDL号 | MFCD00271498 |
参考资料 展开查看 | 1. 李娅琦, 王梓轩, 关彦玲,等. 护肝片中两种主要结合型胆酸的HPLC-ELSD含量测定[J]. 中国药师, 2019, 022(002):350-352. 2. Wang, Tianyang, et al. "Metabolomic profile perturbations of serum, lung, bronchoalveolar lavage fluid, spleen and feces in LPS-induced acute lung injury rats based on HPLC-ESI-QTOF-MS." Analytical and bioanalytical chemistry 412.5 (2020): 1215-1234. 3. Wang, Tianyang, et al. "Metabolomic profile perturbations of serum, lung, bronchoalveolar lavage fluid, spleen and feces in LPS-induced acute lung injury rats based on HPLC-ESI-QTOF-MS." Analytical and bioanalytical chemistry 412.5 (2020): 1215-1234. 4. [IF=3.935] Ziying Liu et al."Promotion of classic neutral bile acids synthesis pathway is responsible for cholesterol-lowing effect of Si-miao-yong-an decoction: Application of LC–MS/MS method to determine 6 major bile acids in rat liver and plasma."J Pharmaceut Bio 5. [IF=5.396] Shiming Huang et al."A sulfated polysaccharide from Gracilaria Lemaneiformis regulates cholesterol and bile acid metabolism in high-fat diet mice."Food Funct. 2019 Jun;10(6):3224-3236 6. [IF=5.396] Cong Liang et al."Lactiplantibacillus plantarum H-87 prevents high-fat diet-induced obesity by regulating bile acid metabolism in C57BL/6J mice."Food Funct. 2021 May;12(10):4315-4324 7. [IF=5.34] Kaihui Zhang et al."A UPLC-MS/MS-based metabolomics analysis of the pharmacological mechanisms of rabdosia serra against cholestasis."Phytomedicine. 2021 Oct;91:153683 8. [IF=3.935] Song Lin et al."A systemic combined nontargeted and targeted LC-MS based metabolomic strategy of plasma and liver on pathology exploration of alpha-naphthylisothiocyanate induced cholestatic liver injury in mice."J Pharmaceut Biomed. 2019 Jul;171:180 9. [IF=3.935] Runjing Zhang et al."Xiaoyan lidan formula ameliorates α-naphthylisothiocyanate-induced intrahepatic cholestatic liver injury in rats as revealed by non-targeted and targeted metabolomics."J Pharmaceut Biomed. 2020 Feb;179:112966 10. [IF=5.396] Juan Wu et al."Sargassum fusiforme polysaccharide is a potential auxiliary substance for metformin in the management of diabetes."Food Funct. 2022 Feb;: 11. [IF=6.558] Yan Cao et al."Widely quasi-quantitative analysis enables temporal bile acids-targeted metabolomics in rat after oral administration of ursodeoxycholic acid."ANALYTICA CHIMICA ACTA. 2022 Jun;1212:339885 |