中文名 | (+)-Cloprostenol |
英文名 | (+)-Cloprostenol |
别名 | 氯前列烯醇 氯前列醇杂质 氯前列醇杂质2 (+)-氯前列醇 (+)-氯前列烯醇 (5Z)-7-[(1R,2R,3R,5S)-2-[(1E,3R)-4-(3-氯苯氧基)-3-羟基-1-丁烯-1-基]-3,5-二羟基环戊基]-5-庚烯酸 |
英文别名 | Superphan cGMP Superphan (+)-Cloprostenol (+)-16-M-CHLOROPHENOXY TETRANOR PROSTAGLANDIN F2ALPHA (+)-9ALPHA,11ALPHA,15-TRIHYDROXY-16-(3-CHLOROPHENOXY)-17,18,19,20-TETRANOR-PROSTA-5Z,13E-DIEN-1-OIC ACID (Z)-7-((1R,2R,3R,5S)-2-((R,E)-4-(3-Chlorophenoxy)-3-hydroxybut-1-en-1-yl)-3,5-dihydroxycyclopentyl)hept-5-enoic acid (5Z)-7-[(1R,2R,3R,5S)-2-[(1E,3R)-4-(3-Chlorophenoxy)-3-hydroxy-1-buten-1-yl]-3,5-dihydroxycyclopentyl]-5-heptenoic acid 5-Heptenoic acid, 7-[(1R,2R,3R,5S)-2-[(1E,3R)-4-(3-chlorophenoxy)-3-hydroxy-1-buten-1-yl]-3,5-dihydroxycyclopentyl]-, (5Z)- |
CAS | 54276-21-0 |
化学式 | C22H29ClO6 |
分子量 | 424.92 |
密度 | 1.321 |
沸点 | 628.0±55.0 °C(Predicted) |
酸度系数 | 4.76±0.10(Predicted) |
存储条件 | 2-8℃ |
体外研究 | D-Cloprostenol and PGF2 alpha are equipotent, about 150 times more potent than dl-cloprostenol (P < 0.05) and approximately 280 times more potent than PGE1 in inhibiting [ 3 H]PGF2 alpha binding to corpus luteum cell membranes. However, d-cloprostenol and PGF2 alpha are about 10 times more potent than dl-cloprostenol and approximately 95 times more potent than PGE1 in myometrial cell membranes. |
体内研究 | D-cloprostenol (15 g per head) is the lowest dose that consistently achieves abortion; D-cloprostenol causes mild adverse effects including salivation, defecation and hyperventilation in bitches weighing less than 10 kg. Intra-vesicle administration of a single low dose of d-cloprostenol is a safe and successful technique to induce abortion in the bitch. |
上游原料 | ETHYL 2-(3-CHLOROPHENOXY)ACETATE 3-氯苯酚 |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.353 ml | 11.767 ml | 23.534 ml |
5 mM | 0.471 ml | 2.353 ml | 4.707 ml |
10 mM | 0.235 ml | 1.177 ml | 2.353 ml |
5 mM | 0.047 ml | 0.235 ml | 0.471 ml |