中文名 | 氟提肟氨 |
英文名 | fluvoxamine |
别名 | 氟伏沙明 氟提肟氨 氟伏沙明-D3 氟伏沙明F603500 马来酸氟伏沙明杂质D3 氟伏沙明 54739-18-3 (E)-5-甲氧基-4-三氟甲基苯戊酮氧-2-氨乙酰基肟 |
英文别名 | Dumirox Faverin Fevarin Floxyfral 54739-18-3 FLUVOXAMINE fluvoxamine δ-Methoxy-4'-(trifluoromethyl)valerophenone (E)-O-(2-aminoethyl)oxime (E)-ω-Methoxy-4'-(trifluoromethyl)valerophenone O-(2-aminoethyl)oxime (1E)-5-Methoxy-1-[4-(trifluoromethyl)phenyl]pentanal O-(2-aminoethyl)oxime 2-[[5-methoxy-1-[4-(trifluoromethyl)phenyl]-pentylidene]amino]oxyethanamine (E)-5-methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanoneo-(2-aminoethyl)oxime (E)-5-Methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone O-(2-Aminoethyl)oxime (1E)-5-methoxy-1-[4-(trifluoromethyl)phenyl]pentan-1-one O-(2-aminoethyl)oxime 2-[({(1E)-5-Methoxy-1-[4-(trifluoromethyl)phenyl]pentylidene}amino)oxy]ethanamine 1-Pentanone, 5-methoxy-1-(4-(trifluoromethyl)phenyl)-, O-(2-aminoethyl)oxime, (E)- 1-pentanone, 5-methoxy-1-[4-(trifluoromethyl)phenyl]-, O-(2-aminoethyl)oxime, (1E)- |
CAS | 54739-18-3 |
EINECS | 611-193-1 |
化学式 | C15H21F3N2O2 |
分子量 | 318.33 |
InChI | InChI=1/C15H21F3N2O2.C4H4O4/c1-21-10-3-2-4-14(20-22-11-9-19)12-5-7-13(8-6-12)15(16,17)18;5-3(6)1-2-4(7)8/h5-8H,2-4,9-11,19H2,1H3;1-2H,(H,5,6)(H,7,8)/b20-14+;2-1- |
密度 | 1.16±0.1 g/cm3(Predicted) |
熔点 | 120-122.5°C |
沸点 | 370.6±52.0 °C(Predicted) |
闪点 | 177.9°C |
蒸汽压 | 1.1E-05mmHg at 25°C |
溶解度 | 氯仿 (微溶),DMSO (微溶),甲醇 (微溶) |
酸度系数 | pKa 8.7 (Uncertain) |
存储条件 | Sealed in dry,2-8°C |
外观 | 滑油 |
颜色 | Colourless |
体内研究 | Fluvoxamine (DU-23000) is effective in inhibiting 5-ht uptake by blood platelets and brain synaptosomes. The antagonism by fluvoxamine of the reserpine-induced lowering of the pentamethylenetetrazole convulsive threshold can be regarded as due to an effect upon 5-HT uptake. In contrast to the effects of desmethylimipramine and imipramine, no stimulatory effects are found in rats when rapidly acting reserpine-like compounds are given following a dose of fluvoxamine. Fluvoxamine (DU-23000) appears to improve combat-related PTSD symptoms but not depressive symptoms. The high attrition rate and lack of a placebo group limits the conclusions of our study. Controlled studies of fluvoxamine in the treatment of PTSD are warranted. Fluvoxamine (DU-23000) was less potent at decreasing ethanol self-administration when food was available concurrently versus when ethanol was available in isolation [ED50: 4.0 (2.7-5.9) and 5.1 (4.3-6.0)]. Effects on food were similar under each condition in which food was available. The results demonstrate that the potency of fluvoxamine in reducing ethanol-maintained behavior depends on whether ethanol is available in isolation or in the context of concurrently scheduled food reinforcement. |
上游原料 | 2-氨基乙氧基胺二盐酸盐 |
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