中文名 | 毛地黄皂苷 |
英文名 | Digitonin |
别名 | 洋地黄皂甙 毛地黄皂苷 毛地S皂苷 毛地黄皂甙 毛地黃皂苷, 脂溶性 洋地黄皂苷,毛地黄皂苷 DIGITONIN-WATER-SOLUBLE 水溶毛地黄皂苷 |
英文别名 | Digitin AI3-44893 NSC 23471 Digitonin Digitonine DigitoninGr BRN 0078654 Digitonin, AR DIGITONIN CRYSTALLINE Digitonin, High Purity Digitogenin, glycoside DIGITONIN, USED AS NON-IONIC DETERGE 5-19-03-00603 (Beilstein Handbook Reference) DIGITONIN (DIGITIN) HIGH PURITY RECEPTOR SOLUBILIZING (2alpha,3beta,5alpha,15beta,25R)-spirostan-2,3,15-triol beta-D-Galactopyranoside, (2alpha,3beta,5alpha,15beta,25R)-2,15-dihydroxyspirostan-3-yl O-beta-D-glucopyranosyl-(1-3)-O-beta-D-galactopyranosyl-(1-2)-O-(beta-D-xylopyranosyl-(1-3))-O-beta-D-glucopyranosyl-(1-4)- beta.-D-Galactopyranoside, (2.alpha.,3.beta.,5.alpha.,15.beta.,25R)-2,15-dihydroxyspirostan-3-yl O-.beta.-D-glucopyranosyl-(1?3)-O-.beta.-D-galactopyranosyl-(1?2)-O-.beta.-D-xylopyranosyl-(1?3)-O-.beta.-D-glucopyranosyl-(1?4)- beta-D-Galactopyranoside, (2alpha,3beta,5alpha,15beta,25R)-2,15-dihydroxyspirostan-3-yl O-beta-D-glucopyranosyl-(1.fwdarw.3)-O-beta-D-galactopyranosyl-(1.fwdarw.2)-O-(beta-D-xylopyranosyl-(1.fwdarw.3))-O-beta-D-glucopyranosyl-(1.fwdarw.4)- |
CAS | 11024-24-1 |
EINECS | 234-255-6 |
化学式 | C56H92O29 |
分子量 | 1229.31 |
InChI | InChI=1/C56H92O29/c1-19-7-10-56(75-17-19)20(2)31-45(85-56)37(67)32-22-6-5-21-11-26(24(61)12-55(21,4)23(22)8-9-54(31,32)3)76-50-42(72)39(69)44(30(16-60)80-50)81-53-48(47(36(66)29(15-59)79-53)83-49-40(70)33(63)25(62)18-74-49)84-52-43(73)46(35(65)28(14-58)78-52)82-51-41(71)38(68)34(64)27(13-57)77-51/h19-53,57-73H,5-18H2,1-4H3/t19-,20+,21+,22-,23+,24-,25-,26-,27-,28-,29-,30-,31+,32-,33+,34-,35+,36?,37+,38+,39-,40-,41-,42-,43-,44+,45-,46+,47+,48-,49+,50-,51+,52+,53+,54-,55+,56-/m1/s1 |
InChIKey | FAAZZWIYYDUONB-JYIJKGCVSA-N |
密度 | 1.1421 (rough estimate) |
熔点 | 230-240°C (dec.)(lit.) |
沸点 | 788.4°C (rough estimate) |
比旋光度 | D20 -54° (0.45 g in 15.8 ml methanol) |
溶解度 | H2O: 10毫克/毫升,在95 ℃ 热,透明,无色 |
折射率 | -52 ° (C=1, EtOH) |
酸度系数 | 12.68±0.70(Predicted) |
存储条件 | Sealed in dry,Room Temperature |
敏感性 | Easily absorbing moisture |
外观 | 白色粉末 |
颜色 | white |
Merck | 14,3161 |
BRN | 78654 |
MDL号 | MFCD00077729 |
体外研究 | Digitonin, a detergent that increases cell permeability by binding to cholesterol molecules in the cell membrane, can increase cisplatin accumulation and reduce tumour growth in vitro. |
体内研究 | In the liver parenchyma the concentrations are of the same magnitude. Measured with the 133 Xe-clearance technique, Digitonin does not alter the tumor blood flow. Digitonin enhances the tumor-growth retarding effect of CBDCA given intra-aterially at 5 mg/kg but not at 25 mg/kg. |
危险品标志 | T - 有毒物品 |
风险术语 | 23/24/25 - 吸入、皮肤接触及吞食有毒。 |
安全术语 | S22 - 切勿吸入粉尘。 S28 - 不慎与皮肤接触后,立即用大量肥皂水冲洗。 S36/37 - 穿戴适当的防护服和手套。 S45 - 若发生事故或感不适,立即就医(可能的话,出示其标签)。 |
危险品运输编号 | UN 3462 6.1/PG 3 |
WGK Germany | 3 |
RTECS | IH2050050 |
FLUKA BRAND F CODES | 3-10 |
海关编号 | 29389090 |
Hazard Class | 6.1(a) |
Packing Group | II |
参考资料 展开查看 | 1. [IF=3.882] Kunpeng Yin et al."Lanthanide Metal–Organic Framework-Based Fluorescent Sensor Arrays to Discriminate and Quantify Ingredients of Natural Medicine."Langmuir. 2021;37(17):5321–5328 2. [IF=2.289] Zhou Shun et al."Anthelmintic efficacy of natural saponins against Gyrodactylus kobayashii in goldfish (Carassius auratus) and their 3D-QSAR analysis."Parasitol Res. 2021 Mar;120(3):1143-1150 |