中文名 | 4-(1-羟基-1-甲基乙基)-2-丙基-1-[2'-(四唑-5-基)苯基]苯基]甲基咪唑-5-羧酸 |
英文名 | 4-(2-Hydroxy-2-propanyl)-2-propyl-1-{[2'-(1H-tetrazol-5-yl)-4-biphenylyl]methyl}-1H-imidazole-5-carboxylic acid |
别名 | 奥美沙坦 奥美沙坦酯A 奥美沙坦侧链 美沙坦酯杂质A 奥美沙坦酯杂质A (EP) 奥美沙坦溶液,100PPM 奥美沙坦溶液,1000PPM 奥美沙坦酸(奥美沙坦EP杂质A) 4-(1-羟基-1-甲基乙基)-2-丙基-1-[2'-(四唑-5-基)苯基]苯基]甲基咪唑-5-羧酸 |
英文别名 | CS 088 CS-415 Olmesartan Olmesartan Acid Olmesartan Medoxomil-1 Olmesartan (Olmesartan Medoxomil EP Impurity A) 4-(2-Hydroxy-2-propanyl)-2-propyl-1-{[2'-(1H-tetrazol-5-yl)-4-biphenylyl]methyl}-1H-imidazole-5-carboxylic acid 4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2'-(1H-tetazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic Acid 4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid 1H-Imidazole-5-carboxylicacid, 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]- 1H-Imidazole-5-carboxylic acid, 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]- |
CAS | 144689-24-7 |
EINECS | 646-413-5 |
化学式 | C24H26N6O3 |
分子量 | 446.5 |
InChI | InChI=1S/C24H26N6O3/c1-4-7-19-25-21(24(2,3)33)20(23(31)32)30(19)14-15-10-12-16(13-11-15)17-8-5-6-9-18(17)22-26-28-29-27-22/h5-6,8-13,33H,4,7,14H2,1-3H3,(H,31,32)(H,26,27,28,29) |
密度 | 1.33 |
熔点 | 186-188°C |
沸点 | 738.3±70.0 °C(Predicted) |
闪点 | 400.3°C |
蒸汽压 | 6.89E-23mmHg at 25°C |
溶解度 | DMSO (微溶),甲醇 (微溶,加热) |
折射率 | 1.671 |
酸度系数 | 2.39±0.50(Predicted) |
存储条件 | 2-8°C |
稳定性 | 吸湿性 |
外观 | 粉末 |
颜色 | white to beige |
体内研究 | Repeated dosing of olmesartan (1 mg/kg, 2 mg/kg, p.o.) dose-dependently decreases mean arterial blood pressure (MAP) in SHR without significant influence on body weight and food intake during 10 weeks. Olmesartan (5 mg/kg/d, p.o.) and Hyd treatments lower systolic blood pressure to the same degree in mice. Olmesartan treatment inhibits cardiac hypertrophy, evaluated by echocardiography, heart weight, cross-sectional area of cardiomyocytes, and gene expression. Olmesartan treatment reverses decreased gene expressions of ACE2 and Mas receptor of Ren-Tg mice and inhibits enhanced NADPH oxidase (Nox)4 expression and reactive oxygen species. |
RTECS | NI4014100 |
海关编号 | 29339900 |
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