中文名 | 苄基十二烷基二甲基氯化铵二水合物 |
英文名 | Benzyldodecyldimethylammonium Chloride Dihydrate |
别名 | 十二烷基二甲基苄基氯化铵水合物 苄基十二烷基二甲基氯化铵二水合物 苄基十二烷基二甲基氯化铵 二水合物 |
英文别名 | Benzyldimethyldodecylammonium Chloride Dihydrate Benzyldodecyldimethylammonium Chloride Dihydrate |
CAS | 147228-80-6 |
化学式 | C21H42ClNO2 |
分子量 | 376.01668 |
熔点 | 44 °C |
存储条件 | Room Temprature |
体外研究 | Benzyldodecyldimethylammonium chloride dihydrate (1-10 μM; 2 hours) results in a dose-dependent changes in the percent population of dead rat thymocyte cells.Benzyldodecyldimethylammonium chloride dihydrate (0-40 mg/L; 0-24 hours) inhibits P. fluorescens with a MIC of 20 mg/L. At 5 mg/L, cells have the same growth behaviour as the control. At concentrations of 10 and 15 mg/L the growth profile is different from the control, and the cells start to grow only after 8 h of adaptation. At concentrations of ≥20 mg/L, BDMDAC inhibits cell growth.Benzyldodecyldimethylammonium chloride dihydrate interacts strongly with cell surfaces in a concentration-dependent manner, and binds by ionic and hydrophobic interactions to microbial membrane surfaces, as manifested by phenomena such as membrane disruption and loss of membrane integrity with consequent leakage of essential intracellular constituents, which promote significant and irreversible changes in the cell structure. Cell Viability Assay Cell Line: Rat thymocyte cells Concentration: 0, 5, 10, 15, 20 and 40 mg/L Incubation Time: 2 hours Result: Resulted in cell death. Cell Proliferation Assay Cell Line: Bacterial P. fluorescen Concentration: 0, 5, 10, 15, 20 and 40 mg/L Incubation Time: 2 hours Result: Inhibited bacterial growth in a time and dose dependent manner. |
参考资料 展开查看 | 1. [IF=5.753] Li Qingzhu et al."Transcriptomic and Metabolomic Analyses Reveals That Exogenous Methyl Jasmonate Regulates Galanthamine Biosynthesis in Lycoris longituba Seedlings."Front Plant Sci. 2021 Sep;0:1933 |
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