中文名 | 五味子丙素 |
英文名 | 13,14-dimethoxy-6,7-dimethyl-5,6,7,8-tetrahydro[1,3]benzodioxolo[5',6':3,4]cycloocta[1,2-f][1,3]benzodioxole (non-preferred name) |
别名 | 五味子丙素 五味子素C 五味子丙素对照品, 五味子丙素(标准品) 五味子丙素(五味子素C) SCHISANDRIN C 五味子丙素 SCHISANDRIN C 五味子丙素 标准品 |
英文别名 | WUWEIZISU C ,8-dimethyl- Schizandrin C Schisandrin C SCHIZANDRIN C (S)-(-)-Schisandrin C Schisandrin C (Schizandrin-C Schisandrin C (S)-(-)-Schisandrin C |
CAS | 61301-33-5 |
化学式 | C22H24O6 |
分子量 | 384.42 |
InChI | InChI=1/C22H24O6/c1-11-5-13-7-15-19(27-9-25-15)21(23-3)17(13)18-14(6-12(11)2)8-16-20(22(18)24-4)28-10-26-16/h7-8,11-12H,5-6,9-10H2,1-4H3 |
密度 | 1.232 |
熔点 | 122-123℃ |
沸点 | 549.2±50.0 °C(Predicted) |
比旋光度 | -54.9°(c1.0,chloroform),-31.4°(c0.587,chloroform) |
闪点 | 226.7°C |
蒸汽压 | 1.5E-11mmHg at 25°C |
溶解度 | 溶于乙酸乙酯、丙酮、氯仿、甲醇等。 |
折射率 | 1.572 |
存储条件 | 2-8℃ |
外观 | 无色片状晶体 |
物化性质 | 无色晶体,可溶于甲醇、乙醇、DMSO等有机溶剂,来源于五味子。 |
MDL号 | MFCD00272170 |
体外研究 | Schisandrin C (25-100 μM; 48 hours) down-regulates expression levels of Bcl-2, Bcl-xL and a concomitant degradation of poly(ADP-ribose) polymerase (PARP). It also activates caspase-3 and -9 in U937 cells.Schisandrin C (25-100 μM; 48 hours) induces apoptosis in a dose-dependent manner. And the fragmentation of genomic DNA is also increased in U937 cells.Schisandrin C (25-100 μM; 72 hours) induces G1 arrest, it down-regulates cyclin D1, cyclin E, cyclin-dependent kinase (Cdk) 4 and E2Fs expression, and also exhibits inhibition of pRB, and up-regulation of the Cdk inhibitor p21(WAF1/CIP1). Western Blot Analysis Cell Line: U937 cells Concentration: 25 μM,50 μM,100 μM Incubation Time: 48 hours Result: Decreased the expression of apoptosis related proteins. Apoptosis Analysis Cell Line: U937 cells Concentration: 25 μM,50 μM,100 μM Incubation Time: 48 hours Result: Induced cell apoptosis. Cell Cycle Analysis Cell Line: U937 cells Concentration: 25 μM,50 μM,100 μM Incubation Time: 48 hours Result: Induced growth inhibition and G1 arrest of U937 cells. |
体内研究 | Schisandrin C (lateral ventricle injection (i.c.v.); 15-150 μg/kg; 5 days) reduces Aβ1-42-induced memory deficits in the Y-maze test. Neurons in the hippocampus of SCH-C (15 μg/kg)-treated group returned to normal level, and and SCH-C group (150 μg/kg) has slight neuroprotective effects Aβ1-42-induced group. SCH-C (15 μg/kg) recoveres the activities of SOD and GSHPx and the ratios of GSH, decreases the levels of ChEtotal in the brain of the Aβ1–42-induced amnesic mice simultaneously. Animal Model: Aβ1-42-induced Alzheimer’s disease mice Dosage: 15-150 μg/kg Administration: Lateral ventricle injection (i.c.v.); 15-150 μg/kg; 5 days Result: Exhibited potent neuroprotective effects linking to anti-ChEtotal activities and anti-oxidative mechanisms in Aβ1-42-induced amnestic mice. |
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