中文名 | 乳酸甲氧苄啶 |
英文名 | trimethoprim lactate |
别名 | 乳酸甲氧苄啶 甲氧苄啶 乳酸盐 乳酸甲氧苄氨嘧啶 乳酸三甲氧苄氨嘧啶 甲氧苄氨嘧啶乳酸盐 2,4-二氨基-5-(3,4,5-三甲氧基苄基)嘧啶乳酸盐 TRIMETHOPRIM LACTATE SALT 乳酸甲氧苄啶 |
英文别名 | Lactic triMethopriM trimethoprim lactate Trimethoprim lactate salt 5-(3,4,5-Trimethoxybenzyl) pyrimidine-2,4-diamine 2-hydroxypropanoate 2,4-DIAMINO-5-(3,4,5-TRIMETHOXYBENZYL)PYRIMIDINE LACTATE 2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine Lactate salt 2,4-diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine lactate salt 5-(3,4,5-triMethoxybenzyl)pyriMidine-2,4-diaMine 2-hydroxypropanoate |
CAS | 23256-42-0 |
EINECS | 245-533-1 |
化学式 | C17H24N4O6 |
分子量 | 380.4 |
InChI | InChI=1/C14H18N4O3.C3H6O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15;1-2(4)3(5)6/h5-7H,4H2,1-3H3,(H4,15,16,17,18);2,4H,1H3,(H,5,6) |
熔点 | 170 - 172°C |
沸点 | 526°C at 760 mmHg |
闪点 | 271.9°C |
水溶性 | Soluble in water |
蒸汽压 | 3.74E-11mmHg at 25°C |
溶解度 | H2O: 可溶物20mg/mL |
存储条件 | Keep in dark place,Inert atmosphere,2-8°C |
外观 | 粉末 |
颜色 | white |
MDL号 | MFCD00171722 |
体外研究 | Trimethoprim interrupts folate metabolism by inhibition of the activity of dihydrofolase reductase (DHFR), which reduces dihydrofolate to tetrahydrofolate (THF). Trimethoprim causes protein aggregation and induction of main heat shock proteins (Hsps) in E. coli cells, which indicates that Trimethoprim presence leads to protein misfolding. Trimethoprim causes induction of DnaK, DnaJ, GroEL, ClpB, and IbpA/B Hsps. Among these Hsps, IbpA/B are most efficiently induced by Trimethoprim and coaggregates with the insoluble proteins. Upon folate stress, deletion of the delta ibpA/B operon resulted in increased protein aggregation but does not influence cell viability. |
体内研究 | In intraperitoneal infections in mice, the CD 50 values for Trimethoprim alone against H. influenzae , S. pneumoniae , E. coli and N. meningitidis , is 150 mg/kg, 335 mg/kg, 27.5 mg/kg and 8.4 mg/kg, respectively. |
危险品标志 | T - 有毒物品 |
风险术语 | R23/24/25 - 吸入、皮肤接触及吞食有毒。 R43 - 与皮肤接触可能致敏。 R61 - 可能对胎儿造成伤害。 |
安全术语 | S22 - 切勿吸入粉尘。 S36/37/39 - 穿戴适当的防护服、手套和护目镜或面具。 S45 - 若发生事故或感不适,立即就医(可能的话,出示其标签)。 S53 - 避免接触,使用前须获得特别指示说明。 |
危险品运输编号 | UN 2811 |
WGK Germany | 3 |
Hazard Class | 6.1(b) |
Packing Group | III |
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