中文名 | TUFTSIN |
英文名 | TUFTSIN TUFTSIN ACETATE SALT HYDRATE |
别名 | 促吞噬素 吞噬刺激素 化合物TUFTSIN 增免疫苏精肽H-THR-LYS-PRO-ARG-OH |
英文别名 | Tuftsin Taftsin TUFTSIN THR-LYS-PRO-ARG TUFTSIN 2ACOH 4H2O THR-LYS-PRO-ARG 2ACOH 4H2O L-Thr-L-Lys-L-Pro-L-Arg-OH Tuftsin hydrate acetate salt TUFTSIN TUFTSIN ACETATE SALT HYDRATE Tuftsin Tuftsin acetate salt hydrate |
CAS | 9063-57-4 |
化学式 | C21H40N8O6 |
分子量 | 500.59 |
密度 | 1.48±0.1 g/cm3(Predicted) |
酸度系数 | 3.60±0.21(Predicted) |
存储条件 | −20°C |
体外研究 | Tuftsin is a tetrapeptide, Thr-Lys-Pro-Arg, which resides in the Fc-domain of the heavy chain of immunoglobulin G. Tuftsin possesses a broad spectrum of activities related primarily to the immune system function and exerts on phagocytic cells, notably on macrophages. Tuftsin's capacity to augment cellular activation is mediated by specific receptors that are identified, characterized, and recently isolated from rabbit peritoneal granulocytes. Tuftsin, a macrophage/microglial activator, dramatically improves the clinical course of experimental autoimmune encephalomyelitis (EAE), a well-established animal model for MS. Tuftsin administration correlates with upregulation of the immunosuppressive Helper-2 Tcell (Th2) cytokine transcription factor GATA-3. Tuftsin promotes phagocytic activity for cells of monocytic origin, such as neutrophils, macrophages and microglia, all of which are thought to express Tuftsin receptors. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 1.998 ml | 9.988 ml | 19.976 ml |
5 mM | 0.4 ml | 1.998 ml | 3.995 ml |
10 mM | 0.2 ml | 0.999 ml | 1.998 ml |
5 mM | 0.04 ml | 0.2 ml | 0.4 ml |