TRANS-4-CARBOXY-5-OCTYL-3-METHYLENEBUTYROLACTONE
C75(3-CARBOXY-4-OCTYL-2-METHYLENEBUTYROLACTONE)
CAS: 218137-86-1
化学式: C14H22O4
| 中文名 | C75 |
| 英文名 | 3-CARBOXY-4-OCTYL-2-METHYLENEBUTYROLACTONE |
| 别名 | 化合物 T10657 |
| 英文别名 | C75 FAS inhibitor C75(C-75 3-CARBOXY-4-OCTYL-2-METHYLENEBUTYROLACTONE TRANS-4-CARBOXY-5-OCTYL-3-METHYLENEBUTYROLACTONE 3-Furancarboxylic acid, tetrahydro-4-methylene-2-octyl-5-oxo- C75(4-Methylene-2-octyl-5-oxo-tetrahydro-furan-3-carboxylicacid) TRANS-TETRAHYDRO-3-METHYLENE-2-OXO-5-N-OCTYL-4-FURANCARBOXYLIC ACID |
| CAS | 218137-86-1 |
| 化学式 | C14H22O4 |
| 分子量 | 254.32 |
| 密度 | 1.08±0.1 g/cm3(Predicted) |
| 沸点 | 432.1±45.0 °C(Predicted) |
| 溶解度 | DMSO: 18 mg/mL |
| 酸度系数 | 3.08±0.40(Predicted) |
| 存储条件 | 2-8°C |
| 外观 | 固体 |
| 颜色 | off-white |
| 体外研究 | C75 inhibits PC3 cell growht with an IC 50 of 35 μM at 24 h. C75 (10-50 μM) also reduces the growth of LNCaP spheroids in a concentration-dependent manner with an IC 50 of 50 μM. (-)-C75 inhibits FAS activity and has a cytotoxic effect on tumor cell lines, without affecting food consumption. (+)-C75 inhibits CPT1 and its administration produces anorexia, suggesting that central inhibition of CPT1 is essential for the anorectic effect of C75. The differential activity of C75 enantiomers may lead to the development of potential new specific drugs for cancer and obesity. |
| 体内研究 | C75 blocks fasting-induced c-Fos expression in the arcuate nucleus (Arc), lateral hypothalamic area (LHA), and paraventricular nucleus (PVN) 10–24 h after i.p. injection. Intraperitoneal administration of C75 at 30 mg/kg body weight inhibits food intake of mice by ≥95% within 2 h after i.p. injection. C75-treated DIO mice has a 50% greater weight loss, and a 32.9% increased production of energy because of fatty acid oxidation. C75 treatment of rodent adipocytes and hepatocytes and human breast cancer cells increases fatty acid oxidation and ATP levels by increasing CPT-1 activity, even in the presence of elevated concentrations of malonyl-CoA. |
| WGK Germany | 3 |
TRANS-4-CARBOXY-5-OCTYL-3-METHYLENEBUTYROLACTONE - 配置溶液浓度参考
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.932 ml | 19.66 ml | 39.321 ml |
| 5 mM | 0.786 ml | 3.932 ml | 7.864 ml |
| 10 mM | 0.393 ml | 1.966 ml | 3.932 ml |
| 5 mM | 0.079 ml | 0.393 ml | 0.786 ml |
最后更新：2024-01-02 23:10:35
供应商列表
现货供应
产品名: 3-CARBOXY-4-OCTYL-2-METHYLENEBUTYROLACTONE 去供应商网站查看 询盘CAS: 218137-86-1
产地: 中国上海
包装: 10mg，2mg，50mg，5mg
价格: 面议、电联、微信、QQ
库存: 现货
电话: 400-900-4166
手机: 18017137653
电子邮件: 3007523013@qq.com
QQ: 3007523013
微信: 18017137653
产品描述: 中文名称：3-CARBOXY-4-OCTYL-2-METHYLENEBUTYROLACTONE ，英文名称：C75，CAS：218137-86-1 ，包装：10 更多
现货供应
产品名: 3-CARBOXY-4-OCTYL-2-METHYLENEBUTYROLACTONE 去供应商网站查看 询盘CAS: 218137-86-1
产地: 中国上海
包装: 10mg，2mg，50mg，5mg
价格: 面议、电联、微信、QQ
库存: 现货
电话: 400-900-4166
手机: 18017137653
电子邮件: 3007523013@qq.com
QQ: 3007523013
微信: 18017137653
产品描述: 中文名称：3-CARBOXY-4-OCTYL-2-METHYLENEBUTYROLACTONE ，英文名称：C75，CAS：218137-86-1 ，包装：10 更多
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