中文名 | Pardoprunox |
英文名 | Pardoprunox |
别名 | 帕多芦诺 |
英文别名 | SLV-308 DU 126891 DU-126891 Pardoprunox pardoprunox (SLV308) 7-(4-Methyl-1-piperazinyl)-2(3H)-benzoxazolone 7-(4-methylpiperazin-1-yl)-3H-1,3-benzoxazol-2-one |
CAS | 269718-84-5 |
EINECS | 604-604-1 |
化学式 | C12H15N3O2 |
分子量 | 233.27 |
密度 | 1.258±0.06 g/cm3(Predicted) |
溶解度 | 10毫米DMSO |
酸度系数 | 9.15±0.70(Predicted) |
存储条件 | -20℃ |
体外研究 | Pardoprunox (SLV-308) acts as a potent but partial D2 receptor agonist (pEC 50 = 8.0 and pA 2 =8.4) with an efficacy of 50% on forskolin stimulated cAMP accumulation. At human recombinant dopamine D3 receptors, Pardoprunox acts as a partial agonist in the induction of [(35)S]GTPgammaS binding (intrinsic activity of 67%; pEC 50 =9.2) and antagonized the dopamine induction of [(35)S]GTPgammaS binding (pA 2 =9.0). Pardoprunox acts as a full 5-HT1A receptor agonist on forskolin induced cAMP accumulation at cloned human 5-HT1A receptors but with low potency (pEC 50 =6.3). |