Omapatrilat
OMAPATRILAT(OMAPATRILAT)
CAS: 167305-00-2
化学式: C19H24N2O4S2
| 中文名 | OMAPATRILAT |
| 英文名 | OMAPATRILAT |
| 别名 | 奥马曲拉 化合物 T16385 (4S,7S,10AS)-4-((S)-2-巯基-3-苯基丙酰氨基)-5-氧代八氢-2H-吡啶并[2,1-B] [1,3]硫杂氮杂-7-甲酸 |
| 英文别名 | VANLEV OMAPATRILAT BMS 186716-01 Omapatrilat (BMS-186716) 7H-Pyrido[2,1-b][1,3]thiazepine-7-carboxylic acid, octahydro-4-[[(2S)-2-mercapto-1-oxo-3-phenylpropyl]amino]-5-oxo-, (4S,7S,10aS)- |
| CAS | 167305-00-2 |
| 化学式 | C19H24N2O4S2 |
| 分子量 | 408.53 |
| 密度 | 1.37±0.1 g/cm3(Predicted) |
| 熔点 | 218-220° |
| 沸点 | 724.2±60.0 °C(Predicted) |
| 比旋光度 | D -78.9° (c = 0.46 in DMF) |
| 酸度系数 | 3.44±0.40(Predicted) |
| 存储条件 | under inert gas (nitrogen or Argon) at 2-8°C |
| 体外研究 | Omapatrilat exhibits high potency for NEP, NEP2 and ACE, moderate strong activity against APP, but low activity against ECE1 (K i =0.45, 25, 0.64, 250 nM) . In vitro autoradiography using the specific NEP inhibitor radioligand 125I-RB104 and the specific ACE inhibitor radioligand 125I-MK351A show omapatril at (10 mg/kg) causes rapid and potent inhibition of renal NEP and ACE, respectively, for 24 h. |
| 体内研究 | Omapatrilat demonstrates excellent blood pressure lowering in a variety of animal models characterized by various levels of plasma renin activity and significantly potentiates urinary sodium, ANP, and cGMP excretion in a cynomolgus monkey assay. Omapatrilat decreases mean arterial pressure (MAP) approximately 40 mmHg below baseline from 10 to 24 h. Oral administration of omapatrilat at 100 μM/kg once daily results in a 38 mmHg decrease in systolic blood pressure at day three as compared to vehicle . Omapatrilat is widely used in experimental protocols related to hypertension and heart failure. Chronic oral administration of omapatrilat reduces aortic leakiness and atheroma formation with enhanced endothelial independent vasorelaxation to ANP. Omapatrilat causes significant inhibition of plasma ACE and increased plasma renin activity in rats. |
Omapatrilat - 配置溶液浓度参考
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.448 ml | 12.239 ml | 24.478 ml |
| 5 mM | 0.49 ml | 2.448 ml | 4.896 ml |
| 10 mM | 0.245 ml | 1.224 ml | 2.448 ml |
| 5 mM | 0.049 ml | 0.245 ml | 0.49 ml |
最后更新：2024-01-02 23:10:35
供应商列表
现货供应
产品名: Omapatrilat 去供应商网站查看 询盘CAS: 167305-00-2
产地: 美国
包装: 10 mM * 1 mL;10 mM * 1 mL;5 mg;5 mg;10 mg;10 mg;25 mg;25 mg;50 mg;50 mg
规格: HY-18208
库存: 现货，货期：1-2天
电话: 021-38924433; 021-58955995
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电子邮件: sales@medchemexpress.cn
产品描述: 产品覆盖：8万多种抑制剂，11000+靶点蛋白，数百款试剂盒，200+生物活性化合物库，天然产物，抗体等. 纯度: 98.87%
现货供应
产品名: OMAPATRILAT 去供应商网站查看 询盘CAS: 167305-00-2
产地: 其他
包装: 10 mg
价格: $159
库存: In stock
电话: +16314854226
手机: +16314854226
电子邮件: info@bocsci.com
产品描述: Omapatrilat, an octahydropyridothiazepine derivative, has been found to be an AC 更多
产品目录: 点此进入
现货供应
产品名: Omapatrilat 去供应商网站查看 询盘CAS: 167305-00-2
产地: 上海
规格: O881586
价格: 10mg-1920,5mg-1280
库存: 7天内发货
电话: 13816333479/17821173903
手机: 13816333479/17821173903
电子邮件: wangrui@macklin.cn
QQ: 2881510266
微信: 19863730987/17821173903
产品名: OMAPATRILAT 去供应商网站查看 询盘
CAS: 167305-00-2
产地: 上海
规格: 97%
价格: 5mg 820,10mg 1450,25mg 3100,50mg 5580
电话: 18301782025
手机: 18301782025
电子邮件: 3008007403@qq.com
QQ: 3008007403
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产品描述: OMAPATRILAT 97% MedMol 货号：S83848
CAS: 167305-00-2
产地: 上海
规格: 97%
价格: 5mg 820,10mg 1450,25mg 3100,50mg 5580
电话: 18301782025
手机: 18301782025
电子邮件: 3008007403@qq.com
QQ: 3008007403
微信: 18301782025
产品描述: OMAPATRILAT 97% MedMol 货号：S83848
现货供应
产品名: Omapatrilat 去供应商网站查看 询盘CAS: 167305-00-2
产地: 美国
包装: 10 mM * 1 mL;10 mM * 1 mL;5 mg;5 mg;10 mg;10 mg;25 mg;25 mg;50 mg;50 mg
规格: HY-18208
库存: 现货，货期：1-2天
电话: 021-38924433; 021-58955995
手机: 18019480960
电子邮件: sales@medchemexpress.cn
产品描述: 产品覆盖：8万多种抑制剂，11000+靶点蛋白，数百款试剂盒，200+生物活性化合物库，天然产物，抗体等. 纯度: 98.87%
现货供应
产品名: OMAPATRILAT 去供应商网站查看 询盘CAS: 167305-00-2
产地: 其他
包装: 10 mg
价格: $159
库存: In stock
电话: +16314854226
手机: +16314854226
电子邮件: info@bocsci.com
产品描述: Omapatrilat, an octahydropyridothiazepine derivative, has been found to be an AC 更多
产品目录: 点此进入
现货供应
产品名: Omapatrilat 去供应商网站查看 询盘CAS: 167305-00-2
产地: 上海
规格: O881586
价格: 10mg-1920,5mg-1280
库存: 7天内发货
电话: 13816333479/17821173903
手机: 13816333479/17821173903
电子邮件: wangrui@macklin.cn
QQ: 2881510266
微信: 19863730987/17821173903
产品名: OMAPATRILAT 去供应商网站查看 询盘
CAS: 167305-00-2
产地: 上海
规格: 97%
价格: 5mg 820,10mg 1450,25mg 3100,50mg 5580
电话: 18301782025
手机: 18301782025
电子邮件: 3008007403@qq.com
QQ: 3008007403
微信: 18301782025
产品描述: OMAPATRILAT 97% MedMol 货号：S83848
CAS: 167305-00-2
产地: 上海
规格: 97%
价格: 5mg 820,10mg 1450,25mg 3100,50mg 5580
电话: 18301782025
手机: 18301782025
电子邮件: 3008007403@qq.com
QQ: 3008007403
微信: 18301782025
产品描述: OMAPATRILAT 97% MedMol 货号：S83848
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