中文名 | Nω-单甲基-L-精氨酸乙酸盐 |
英文名 | (2S)-5-{[(E)-amino(methyliminio)methyl]amino}-2-ammoniopentanoate |
别名 | NG-甲基-L-精氨酸醋酸盐 NG-单甲基-L-精氨酸醋酸盐 NG-单甲基-L-精氨酸乙酸盐 Nω-单甲基-L-精氨酸乙酸盐 N-单甲基-L-精氨酸单乙酸酯 N5-[亚氨基(甲基氨基)甲基]-L-鸟氨酸单乙酸盐 N蠅-MONOMETHYL-L-ARGININE ACETATE |
英文别名 | Nα-Methyl-L-arginine N-Monomethyl-L-arginine Ngamma-methyl-L-arginine acetate NG-Monomethyl-L-arginine acetate salt L-NG-Monomethylarginine, Acetate Salt (L-NMMA) (2S)-5-{[(E)-amino(methyliminio)methyl]amino}-2-ammoniopentanoate L-NMMA, NG-Monomethyl-L-arginine acetate salt, Nω-Methyl-L-arginine acetate salt, N5-(Methylamidino)-L-ornithine acetate salt |
CAS | 53308-83-1 |
化学式 | C9H20N4O4 |
分子量 | 248.28 |
InChI | InChI=1/C7H16N4O2/c1-10-7(9)11-4-2-3-5(8)6(12)13/h5H,2-4,8H2,1H3,(H,12,13)(H3,9,10,11)/p+1/t5-/m0/s1 |
InChIKey | IKPNWIGTWUZCKM-JEDNCBNOSA-N |
密度 | 1.2162 (rough estimate) |
熔点 | 180-190 °C |
沸点 | 391.35°C (rough estimate) |
比旋光度 | D22 +9.5° (c = 0.10 in water) |
闪点 | 191.3°C |
蒸汽压 | 2.92E-07mmHg at 25°C |
溶解度 | H2O: 1mg/ml,澄清,无色 |
折射率 | 1.6300 (estimate) |
存储条件 | 2-8°C |
稳定性 | 储存在-5 °C; 建议干燥 |
外观 | 粉末 |
颜色 | White to Off-white |
BRN | 6674255 |
体外研究 | L-NMMA, starting from 100 μM, produces a concentration-dependent inhibition of the evoked relaxations (2Hz); maximal inhibition at 1 mM averaged about 35%. The inhibitory effect of L-NMMA is unchanged by previous incubation with D-arginine while it is prevented by L-arginine (L-Arg). L-NMMA does not affect isoprenaline-induced relaxation. Superfusion of L-NMMA reduces arteriolar diameter and causes dose-dependent increases in arteriolar tone. The onset of action of L-NMMA is nearly immediate. L-NMMA inhibits vasodilator responses to the endothelium-dependent vasodilator ACh but not to the endothelium-independent NP. NE induced dose-related vasoconstriction that is significantly potentiated by L-NMMA. |
安全术语 | S22 - 切勿吸入粉尘。 S24/25 - 避免与皮肤和眼睛接触。 |
WGK Germany | 3 |
海关编号 | 29252900 |