Nemorubicin
莫柔比星(Nemorubicin)
CAS: 108852-90-0
化学式: C32H37NO13
| 中文名 | 莫柔比星 |
| 英文名 | Nemorubicin |
| 别名 | 莫柔比星 柰莫柔比星 奈莫柔比星 |
| 英文别名 | DMM Dox FCE 23762 PNU152243A Nemorubicin PNU 152243A NEMORUBICIN PNU-152243A NeMorubincine METHOXYMORPHOLINYL-DOXORUBICIN methoxy-morpholynil-doxorubicin (1S,3S)-3-Glycoloyl-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1-naphthacenyl 2,3,6-trideoxy-3-[(S)-2-methoxymorpholino]-alpha-L-lyxo-hexopyranoside 5,12-Naphthacenedione, 7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-10-2,3,6-trideoxy-3-(2S)-2-methoxy-4-morpholinyl-.alpha.-L-lyxo-hexopyranosyloxy-, (8S,10S)- |
| CAS | 108852-90-0 |
| 化学式 | C32H37NO13 |
| 分子量 | 643.64 |
| 密度 | 1.55±0.1 g/cm3(Predicted) |
| 沸点 | 852.2±65.0 °C(Predicted) |
| 溶解度 | 10毫米DMSO |
| 酸度系数 | 7.35±0.60(Predicted) |
| 存储条件 | 2-8℃ |
| 体外研究 | Nemorubicin has antitumor activity, with IC 70 s of 578 nM, 468 nM, 193 nM, 191 nM, 68 nM, and 131 ± 9 nM for HT-29, A2780, DU145, EM-2, Jurkat and CEM cell lines, respectively. Nemorubicin is CYP3A-activated anticancer prodrug, which can produce a more cytotoxic metabolite, PNU-159682. Nemorubicin acts through nucleotide excision repair (NER) system to exert its activity. Nemorubicin (0-0.3 μM) is more active in the L1210/DDP cells with intact NER than in the XPG-deficient L1210/0 cells. Cells resistant to nemorubicin show increased sensitivity to UV damage. Nemorubicin is cytotoxic to 9L/3A4 cells, with an IC 50 of 0.2 nM, 120-fold lower than that of P450-deficient 9L cells (IC 50 , 23.9 nM). Nemorubicin also potently inhibits Adeno-3A4 infected U251 cells with IC 50 of 1.4 nM. P450 reductase overexpression enhances cytotoxicity of Nemorubicin. |
| 体内研究 | Nemorubicin is converted to PNU-159682 by human liver cytochrome P450 (CYP) 3A4 in rat, mouse, and dog liver microsomes. Nemorubicin (60 µg/kg) induces sifnificant tumor growth delay in scid mice bearing 9L/3A4 tumors, but shows no obvious effect on the tumor growth delay of 9L tumors in mice by i.v. or intratumoral injection (i.t.). Nemorubicin (40 µg/kg, i.p.) exhibits no antitumor activity and no host toxicity in mice bearing 9L/3A4 tumors. |
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产品名: Nemorubicin 去供应商网站查看 询盘CAS: 108852-90-0
产地: 美国
包装: 询盘
规格: HY-15794G
价格: 询价
库存: 询盘
电话: 021-38924433; 021-58955995
手机: 18019480960
电子邮件: sales@medchemexpress.cn
产品描述: 产品覆盖：8万多种抑制剂，11000+靶点蛋白，数百款试剂盒，200+生物活性化合物库，天然产物，抗体等. 纯度:
现货供应
产品名: Nemorubicin 去供应商网站查看 询盘CAS: 108852-90-0
产地: 上海
规格: N884618
价格: 5mg-8659,1mg-4520
库存: 7天内发货
电话: 13816333479/17821173903
手机: 13816333479/17821173903
电子邮件: wangrui@macklin.cn
QQ: 2881510266
微信: 19863730987/17821173903
提供多种规格现货供应
产品名: Nemorubicin 去供应商网站查看 询盘CAS: 108852-90-0
产地: 美国
包装: 询盘
规格: HY-15794G
价格: 询价
库存: 询盘
电话: 021-38924433; 021-58955995
手机: 18019480960
电子邮件: sales@medchemexpress.cn
产品描述: 产品覆盖：8万多种抑制剂，11000+靶点蛋白，数百款试剂盒，200+生物活性化合物库，天然产物，抗体等. 纯度:
现货供应
产品名: Nemorubicin 去供应商网站查看 询盘CAS: 108852-90-0
产地: 上海
规格: N884618
价格: 5mg-8659,1mg-4520
库存: 7天内发货
电话: 13816333479/17821173903
手机: 13816333479/17821173903
电子邮件: wangrui@macklin.cn
QQ: 2881510266
微信: 19863730987/17821173903
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