中文名 | ML346 |
英文名 | ML346 |
别名 | 化合物ML346 HSP70激动剂(ML346) 5-(3-(4-甲氧基苯基)烯丙基亚基)嘧啶-2,4,6(1H,3H,5H)-三酮 5-[3-(4-甲氧基苯基)-2-丙烯-1-基]-2,4,6(1H,3H,5H)-嘧啶三酮 |
英文别名 | ML346 ML 346 CS-2056 ML346 - CID 767276 5-(3-(4-Methoxyphenyl)allylidene)pyrimidine-2,4,6(1H,3H,5H)-trione 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-[3-(4-methoxyphenyl)-2-propen-1-ylidene]- |
CAS | 100872-83-1 |
EINECS | 604-604-1 |
化学式 | C14H12N2O4 |
分子量 | 272.26 |
密度 | 1.374±0.06 g/cm3(Predicted) |
熔点 | 266-268 °C(Solv: ethyl acetate (141-78-6)) |
溶解度 | DMSO: ≥ 29 mg/mL |
酸度系数 | 7.42±0.20(Predicted) |
存储条件 | -20℃ |
体外研究 | ML346 is an activator of Hsp70, with an EC 50 of 4600 nM in HeLa cells. ML346 (10 μM) restores proteostasis, restores CFTR-mediated iodide conductance, and enhances the correct folding of proteins expressed in two different cellular compartments. ML346 (Compound F1) induces multiple responses and strongly induces Hsp70, the oxidative stress response genes (HO1 and GCLM), and a 2.5-fold upregulation of BiP in WT MEF cells. ML346 (0.5-25 μM) exhibits cytoprotective effects in cells after a 35 min severe heat shock, and also causes a two-fold protection from H 2 O 2 -induced apoptosis. |
体内研究 | ML346 suppress the aggregation of polyQ35 in a C. elegans model, suggesting the probe has efficacy in modifying protein aggregation and associated toxicity. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 3.673 ml | 18.365 ml | 36.73 ml |
5 mM | 0.735 ml | 3.673 ml | 7.346 ml |
10 mM | 0.367 ml | 1.837 ml | 3.673 ml |
5 mM | 0.073 ml | 0.367 ml | 0.735 ml |