中文名 | ML-213 |
英文名 | ML-213 |
别名 | 化合物ML213 N-均三甲基苯基双环[2.2.1]庚烷-2-甲酰胺 N-(2,4,6-三甲基苯基)-双环[2.2.1]庚烷-2-甲酰胺 |
英文别名 | ML213 ML 213 ML-213 CS-2507 CID3111211 CID 3111211 ML-213(CID-3111211) N-(2,4,6-TriMethylphenyl)-bicyclo[2.2.1]heptane-2-carboxaMide Bicyclo[2.2.1]heptane-2-carboxamide, N-(2,4,6-trimethylphenyl)- |
CAS | 489402-47-3 |
EINECS | 803-886-4 |
化学式 | C17H23NO |
分子量 | 257.37 |
密度 | 1.106±0.06 g/cm3(Predicted) |
沸点 | 398.8±11.0 °C(Predicted) |
溶解度 | DMSO: 可溶5mg/mL,澄清 (温热) |
酸度系数 | 14.79±0.70(Predicted) |
存储条件 | Sealed in dry,2-8°C |
外观 | 粉末 |
颜色 | white to beige |
体外研究 | ML213 (100 nM-30 µM) increases maximal conductance to a peak at 212% ± 27% of control, with an EC 50 of 0.8 ± 0.3 µM. ML213 (10 µM) reduces the deactivation rates of Kv7.4 currents by 4.6-fold in the voltage range from −130 mV to −90 mV. ML213 is a potent and effective activator of homomeric Kv7.5 channels overexpressed in A7r5 cells. ML213 increases maximal conductance of Kv7.5 channels with an EC 50 of 0.7 ± 0.2 µM. ML213 (10 µM) also reduces deactivation rates of Kv7.5 currents by 5.9-fold on average. ML213 produces similar effects on heteromeric Kv7.4/7.5 channels: 204% ± 11% maximal increase in conductance with an EC 50 of 1.1 ± 0.6 µM and a 34.2 ± 3.3 mV maximal negative shift of the activation curve, with an EC 50 of 3.8 ± 1.2 µM. ML213 causes a vasorelaxation in different precontracted rat blood vessels. ML213 (10 μM) also hyperpolarizes mesenteric artery smooth muscle cells. ML213 causes a concentration-dependent shift in the V1/2 for KCNQ2 activation with an EC 50 340 ± 70 nM and a maximal shift of 37.4 mV. |
危险品标志 | Xi - 刺激性物品 |
风险术语 | 36/37/38 - 刺激眼睛、呼吸系统和皮肤。 |
安全术语 | 26 - 不慎与眼睛接触后,请立即用大量清水冲洗并征求医生意见。 |
WGK Germany | 3 |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 3.885 ml | 19.427 ml | 38.855 ml |
5 mM | 0.777 ml | 3.885 ml | 7.771 ml |
10 mM | 0.389 ml | 1.943 ml | 3.885 ml |
5 mM | 0.078 ml | 0.389 ml | 0.777 ml |