Lesopitron_化工百科

中文名	lesopitron
英文名	lesopitron
别名	来索吡琼二盐酸盐化合物 T11839
英文别名	E4424 lesopitron Lesopitron (dihydrochloride)
CAS	132449-89-9
化学式	C15H22Cl2N6
分子量	357.28
熔点	194-197.5°
存储条件	Room Temprature
体外研究	In vitro binding and autoradiographic studies with [ 3 H]8-OH-DPAT and [ 3 H]Lesopitron as radioligands confirm that Lesopitron binds to 5-HT 1A receptors in the rat brain with a relatively high affinity (pK i =7.35). As expected of a full agonist at postsynaptic 5-HT 1A receptors, Lesopitron (IC 50 =125 nM) inhibits forskolin-stimulated adenylate cyclase activity in rat hippocampal membranes to the same extent as 5-HT. Lesopitron inhibits the firing of serotoninergic neurons both in vitro (in brainstem slices, IC 50 =120 nM).
体内研究	Lesopitron inhibits the firing of serotoninergic neurons both in vivo (in chloral hydrate-anaesthetized rats, ID 50 =35 μg/kg i.v.). Lesopitron administered at a dose which induces anxiolytic behaviour in rats (30 μg/kg, i.p.) markedly reduces 5-HT levels (to 45% of the basal value) in cortical perfusates.

MedChemExpress

现货供应

产品名: Lesopitron 去供应商网站查看询盘
CAS: 132449-89-9
产地: 美国
包装: 1 mg
规格: HY-101609
库存: 现货，货期：1-2天
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产品描述: 产品覆盖：8万多种抑制剂，11000+靶点蛋白，数百款试剂盒，200+生物活性化合物库，天然产物，抗体等. 纯度: ≥98.0%

上海麦克林生化科技股份有限公司

现货供应

产品名: 来索吡琼二盐酸盐去供应商网站查看询盘
CAS: 132449-89-9
产地: 上海
规格: L911725
价格: 5mg-27000
库存: 7天内发货
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