中文名 | KEA1-97 |
英文名 | KEA1-97 |
别名 | 化合物KEA1-97 |
英文别名 | KEA1-97 1,3,5-Triazin-2-amine, 4,6-dichloro-N-(4'-fluoro[1,1'-biphenyl]-4-yl)- |
CAS | 2138882-71-8 |
化学式 | C15H9Cl2FN4 |
分子量 | 335.16 |
密度 | 1.466±0.06 g/cm3(Predicted) |
沸点 | 530.3±52.0 °C(Predicted) |
溶解度 | 溶于DMSO |
酸度系数 | 0.57±0.10(Predicted) |
存储条件 | -20℃ |
产品用途 | KEA1-97 is a thioredoxin-caspase 3 interaction disruptor. It has been shown to impair breast cancer pathogenicity. KEA1-97 disrupts the interaction of thioredoxin with caspase 3, activates caspases, and induces apoptosis without affecting thioredoxin activity. Moreover, KEA1-97 impairs in vivo breast tumor xenograft growth. |
参考资料 展开查看 | 1: Anderson KE, To M, Olzmann JA, Nomura DK. Chemoproteomics-Enabled Covalent Ligand Screening Reveals a Thioredoxin-Caspase 3 Interaction Disruptor That Impairs Breast Cancer Pathogenicity. ACS Chem Biol. 2017 Oct 20;12(10):2522-2528. doi: 10.1021/acschembio.7b00711. Epub 2017 Sep 13. PubMed PMID: 28892616. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 0 ml | 0 ml | 0 ml |
5 mM | 0 ml | 0 ml | 0 ml |
10 mM | 0 ml | 0 ml | 0 ml |
5 mM | 0 ml | 0 ml | 0 ml |
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