中文名 | KD-3010 |
英文名 | KD-3010 |
别名 | 化合物 T11747 |
英文别名 | KD-3010 |
CAS | 934760-92-6 |
化学式 | C30H33F3N2O8S2 |
分子量 | 670.72 |
体内研究 | To determine whether PPARδ agonists are beneficial in experimental liver fibrosis, mice are treated orally with a PPARδ agonist, KD-3010, or with the well-validated PPARδ agonist GW501516. KD-3010, but not GW501516, shows hepatoprotective and antifibrotic effects in liver fibrosis induced by carbon tetrachloride (CCl 4 ) or bile duct ligation (BDL). Liver injury is induced by repeated injections of CCl 4 , and mice are treated daily with vehicle, the widely used PPARδ agonist GW501516, or the PPARδ agonist KD-3010 by oral gavage. Control oil-injected mice do not show any liver damage. Liver injury consisting of hepatocyte death and inflammation is seen in the vehicle- or GW501516-treated group injected with CCl 4 on H&E-stained liver sections but is markedly reduced in the KD3010-treated group. |
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