中文名 | RG14620 |
英文名 | RG14620 |
别名 | 化合物RG 14620 酪氨酸磷酸化抑制剂RG14620 EGFR抑制剂(RG14620) TYRPHOSTIN RG 14620 酪氨酸磷酸化抑制剂RG14620 |
英文别名 | RG14620 RG-14620 RG 14620 RG-14620 TYRPHOSTIN RG 14620 TYRPHOSTIN RG14620 RG 14620,, 136831-49-7 2-(3-Pyridinyl)-3-(3,5-dichlorophenyl)propenenitrile 2-(3',5'-DICHLOROPHENYL)-1-(3''-PYRIDINYL)ACRYLONITRILE 3-Pyridineacetonitrile,a-[(3,5-dichlorophenyl)methylene]- |
CAS | 136831-49-7 |
化学式 | C14H8Cl2N2 |
分子量 | 275.13 |
密度 | 1.355±0.06 g/cm3(Predicted) |
熔点 | 150-151℃ |
沸点 | 418.2±45.0 °C(Predicted) |
溶解度 | DMSO: 可溶性 |
酸度系数 | 2.97±0.12(Predicted) |
存储条件 | −20°C |
敏感性 | Light Sensitive |
体外研究 | RG14620 inhibits colony formation (IC 50 =3 μM) and DNA synthesis (IC 50 =1 μM) by HER 14 cells, which are stimulated by 50 ng/mL EGF, in a dose-dependent manner. RG14620 also suppresses colony formation(IC 50 =4 μM) and DNA synthesis (IC 50 =1.25 μM) by EGF-stimulated MH-85 cells in a dose-dependent manner. The growth-inhibitory effect of RG14620 irreversible. |
体内研究 | RG14620, at a dose of 200 g/mouse/day inhibits H-85 tumor growth in nude mice. Mice show less cachexia and hypercalcemia, eat more food, and are more active than untreated MH-85 tumor-bearing animals. |
安全术语 | S22 - 切勿吸入粉尘。 S24/25 - 避免与皮肤和眼睛接触。 |
WGK Germany | 3 |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 3.635 ml | 18.173 ml | 36.346 ml |
5 mM | 0.727 ml | 3.635 ml | 7.269 ml |
10 mM | 0.363 ml | 1.817 ml | 3.635 ml |
5 mM | 0.073 ml | 0.363 ml | 0.727 ml |
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