中文名 | CPD2802 |
英文名 | Ingliforib; CP 368296 GPi 296 |
别名 | 化合物INGLIFORIB |
英文别名 | 296 CP296 CP 296 CP-296 CPD2802 GPi 296 CP368296 CP 368296 CP-368296 Ingliforib; CP 368296 |
CAS | 186392-65-4 |
化学式 | C23H24ClN3O5 |
分子量 | 457.91 |
密度 | 1.495±0.06 g/cm3(Predicted) |
熔点 | 238 °C |
沸点 | 843.3±65.0 °C(Predicted) |
溶解度 | DMSO: 130毫克/毫升 (283.90毫米; 需要超声波) |
酸度系数 | 12.88±0.20(Predicted) |
存储条件 | -20°C |
体外研究 | Ingliforib is a glycogen phosphorylase inhibitor, and inhibits the myocardial GP isoforms (muscle and brain) with IC 50 s of 352 and 150 nM, respectively, also a potent inhibitor of the liver isoform (IC 50 of 52 nM). Ingliforib (0.1, 1, 10 μM) dose-dependently reduces infarct size in the isolated rabbit hearts. |
体内研究 | Ingliforib (15 mg/kg) potently reduces infarct size by 52%, and decreases plasma glucose and lactate concentrations in openchest anesthetized rabbits. Ingliforib (15 mg/kg) also inhibits myocardial glycogen phosphorylase a (GPa) and total glycogen phosphorylase (GP) activity in anesthetized rabbits. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.184 ml | 10.919 ml | 21.838 ml |
5 mM | 0.437 ml | 2.184 ml | 4.368 ml |
10 mM | 0.218 ml | 1.092 ml | 2.184 ml |
5 mM | 0.044 ml | 0.218 ml | 0.437 ml |