中文名 | CL2A-SN-38 |
英文名 | CL2A-SN-38 |
英文别名 | CL2A-SN-38 |
CAS | 1004548-96-2 |
化学式 | C77H101Cl4N11O26 |
分子量 | 1479.681 |
溶解度 | 溶于DMSO |
存储条件 | -20°C |
产品用途 | CL2A-SN-38 是 drug-linker conjugate,由 linker CL2A 和 毒性分子 SN-38 连接而成的,可用来制备抗体偶联药物。CL2A-SN-38 针对人类实体瘤表现出特异性的抗肿瘤作用。SN-38 是一种 DNA Topoisomerase I 抑制剂。CL2A 是一种不可降解 (non-cleavable) 的含 PEG8-和三偶氮的 PBC-肽-mc linker。CL2A 通过 pH 敏感性降解,产生旁观者效应,并通过二硫键与抗体结合在半胱氨酸残基上。(CL2A-SN38 is a SN38 derivative with a peptide-linker which can easily react with antibody to form an antibody-drug conjugate (ADC). CL2A-SN-38 is composed of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make antibody drug conjugate (ADC). CL2A-SN-38 provides significant and specific antitumor effects against a range of human solid tumor types. CL2A is a noncleavable complicated PEG8- and triazole-containing PABC-peptide-mc linker. CL2A is cleavable through pH sensitivity, givingrise to bystander effect, and binds the antibody at a cysteine residue via a disulfide bond。) |
参考资料 展开查看 | 1. [IF=6.4] Ye Bi et al."Liposomal codelivery of an SN38 prodrug and a survivin siRNA for tumor therapy."Int J Nanomed. 2018; 13: 5811–5822 |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 0.676 ml | 3.379 ml | 6.758 ml |
5 mM | 0.135 ml | 0.676 ml | 1.352 ml |
10 mM | 0.068 ml | 0.338 ml | 0.676 ml |
5 mM | 0.014 ml | 0.068 ml | 0.135 ml |
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