中文名 | CAMOBUCOL |
英文名 | CAMOBUCOL |
别名 | 化合物 T14861 |
英文别名 | CAMOBUCOL AGIX 4207 Acetic acid,2-[4-[[1-[[3,5-bis(1,1-diMethylethyl)-4-hydroxyphenyl]thio]-1-Methylethyl]thio]-2,6-bis(1,1-diMethylethyl)phenoxy]- |
CAS | 216167-92-9 |
化学式 | C33H50O4S2 |
分子量 | 574.88 |
密度 | 1.11±0.1 g/cm3(Predicted) |
熔点 | 164-165 °C |
沸点 | 622.6±55.0 °C(Predicted) |
酸度系数 | 3.23±0.10(Predicted) |
存储条件 | Room Temprature |
体外研究 | Camobucol exhibits potent antioxidant activity toward lipid peroxides in vitro and displays enhanced cellular uptake. Camobucol selectively inhibits tumor necrosis factor (TNF)-α-inducible levels of the redox-sensitive genes, vascular cell adhesion molecule-1 and monocyte chemoattractant protein-1, with less inhibition of E-selectin, and no effect on intracellular adhesion molecule-1 expression in endothelial cells. In addition, Camobucol inhibits cytokine-induced levels of monocyte chemoattractant protein-1, interleukin (IL)-6, and IL-8 from endothelial cells and human fibroblast-like synoviocytes as well as lipopolysaccharide-induced release of TNF-α, IL-1β, and IL-6 from human peripheral blood mononuclear cells. Camobucol does not inhibit TNF-α-induced nuclear translocation of nuclear factor of the κ-enhancer in B cells (NF-κB), suggesting that the mechanism of action is independent of this redox-sensitive transcription factor. |
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