中文名 | BYK204165 |
英文名 | 4-[(1-Methyl-1H-Pyrrol-2-yl)Methylene]-1,3(2H,4H)-Isoquinolinedione |
别名 | 化合物BYK204165 4-((1-甲基-1H-吡咯-2-基)亚甲基)异喹啉-1,3(2H,4H)-二酮 |
英文别名 | RT-017290 BYK204165 BYK 204165 PARP Inhibitor XIV 4-(1-methyl-1H-pyrrol-2-ylmethylene)-4H-isoquinolin-1,3-dione 4-(1-Methyl-1H-pyrrol-2-ylmethylene)-4H-isoquinoline-1,3-dione 4-[(1-Methyl-1H-Pyrrol-2-yl)Methylene]-1,3(2H,4H)-Isoquinolinedione 4-[(1-Methyl-1H-pyrrol-2-yl)methylene]-1,3(2H,4H)-isoquinolinedione 1,3(2H,4H)-Isoquinolinedione, 4-[(1-methyl-1H-pyrrol-2-yl)methylene]- |
CAS | 1104546-89-5 |
化学式 | C15H12N2O2 |
分子量 | 252.27 |
密度 | 1.27±0.1 g/cm3(Predicted) |
沸点 | 492.5±45.0 °C(Predicted) |
溶解度 | DMSO: >20 mg/mL |
酸度系数 | 9.30±0.20(Predicted) |
存储条件 | 2-8°C |
外观 | 粉末 |
颜色 | yellow |
体外研究 | In kinetic experiments with human PARP-1, BYK204165 exhibits potent and competitive inhibition of enzyme activity, yielding a pK i value of 7.05. BYK204165 exhibits low potency of PARP inhibition in C4I cells (pIC 50 of 5.75). |
体内研究 | BYK204165 is not investigated in vivo because of its short half-time (t 1/2 ) of 23 min measured at rat microsomes in vitro. |
危险品标志 | Xi - 刺激性物品 |
风险术语 | 43 - 与皮肤接触可能致敏。 |
安全术语 | 36/37 - 穿戴适当的防护服和手套。 |
WGK Germany | 3 |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 3.964 ml | 19.82 ml | 39.64 ml |
5 mM | 0.793 ml | 3.964 ml | 7.928 ml |
10 mM | 0.396 ml | 1.982 ml | 3.964 ml |
5 mM | 0.079 ml | 0.396 ml | 0.793 ml |
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