中文名 | 豚鼠髓磷脂碱性蛋白片段68-82 |
英文名 | des-gly77 |
别名 | 髓鞘碱性蛋白豚鼠片段 68-82 豚鼠髓磷脂碱性蛋白片段68-82 L-酪氨酰甘氨酰-L-丝氨酰-L-亮氨酰-L-脯氨酰-L-谷氨酰胺酰-L-赖氨酰-L-丝氨酰-L-谷氨酰胺酰-L-精氨酰-L-丝氨酰-L-谷氨酰胺酰-L-ALPHA-天冬氨酰-L-ALPHA-谷氨酰-L-天冬氨酰胺 |
英文别名 | des-gly77 DES[GLY77,HIS78]-MYELIN BASIC PROTEIN, FRAGMENT 68-64 DES-[GLY77,HIS78] MYELIN BASIC PROTEIN (68-84), BOVINE TYR-GLY-SER-LEU-PRO-GLN-LYS-SER-GLN-ARG-SER-GLN-ASP-GLU-ASN (DES-GLY77,DES-HIS78)-MYELIN BASIC PROTEIN (68-84) (BOVINE) Tyr-Gly-Ser-Leu-Pro-Gln-Lys-Ser-Gln-Arg-Ser-Gln-Asp-Glu-Asn DES-GLY77, DES-HIS78-MYELIN BASIC PROTEIN FRAGMENT 68-84 BOVINE (DES-GLY77,DES-HIS78)-MYELIN BASIC PROTEIN (68-84) (GUINEA PIG) H-TYR-GLY-SER-LEU-PRO-GLN-LYS-ALA-GLN-ARG-PRO-GLN-ASP-GLU-ASN-OH H-TYR-GLY-SER-LEU-PRO-GLN-LYS-SER-GLN-ARG-SER-GLN-ASP-GLU-ASN-OH DES[GLY77, HIS78]-SER75,80-MYELIN BASIC PROTEIN BOVINE FRAGMENT 68-84 |
CAS | 98474-59-0 |
化学式 | C71H113N23O28 |
分子量 | 1736.81 |
存储条件 | -20°C |
MDL号 | MFCD00076871 |
体外研究 | Multiple sclerosis is the most common autoimmune disorder affecting the central nervous system. In this study, whole blood samples are analyzed for activation capacity and the activatability of CD4 + and CD8 + T-lymphocytes by human total myelin basic protein (MBP), human MBP 104-118 fragment, and guinea pig MBP (68-82) fragment. A significant increase in the number of activated T-lymphocytes was observed in the whole blood. For all three tested MBPs, this increase in activated CD4 + and CD8 + T-lymphocytes is statistically significant (p<0.01). However, this increase in activated T-cells is most prominent following incubation with human total MBP, followed by human 104-118 fragment; the smallest increase is observed following incubation with guinea pig MBP (68-82) fragment (human total MBP>huMBP-104-118>guinea pig MBP (68-82)). |
体内研究 | Whether pretreatment with bee venom acupuncture (BVA) from the same day of MBP (68-82) immunization can affect the induction and progression of experimental autoimmune encephalomyelitis (EAE) and weight loss is examined. At 5-9 days after immunization, rats in the myelin basic protein (MBP) group start displaying partial loss of tail tonus (clinical signs, 0.5) in a freely moving environment. At 10-16 days after immunization, most of the rats in the MBP group display more severe symptoms of neurological deficit including paraparesis of the hindlimb, paraplegia, tetraparesis, and tetraplegia. In contrast, rats in the MBP + BVA group display relatively slight neurological deficits in a dose-dependent manner at 11-15 days after immunization, compared to the rats in the MBP group. The onset of symptoms is slightly delayed (BVA 0.8 mg/kg, 6.4±0.6 days) and the maximal clinical score is markedly decreased (BVA 0.25 mg/kg, 3.7±0.2; BVA 0.8 mg/kg, 2.8±0.3), compared to that in the MBP group. At this time, the mean body weight of rats in the MBP group is decreased as compared to that of rats in the normal group, but it is significantly increased in rats of the MBP + BVA group as compared to rats in the MBP group. |
WGK Germany | 3 |