中文名 | U-46619 |
英文名 | 9,11-二脱氧基-9Α,11Α-亚甲基环氧前列腺素 |
别名 | 化合物 T17189 9,11-二脱氧基-9Α,11Α-亚甲基环氧前列腺素 9,11-二脱氧基-11Α,9Α-亚甲基环氧前列腺素 F2Α 9,11-二脱氧基-9Α,11Α-亚甲基环氧前列腺素 F2Α溶液 |
英文别名 | U-46619 9,11-DIDEOXY-11ALPHA,9ALPHA-EPOXYMETHANO 9,11-dideoxy-11α,9α-epoxymethanoprostaglandin f2α 9,11-DIDEOXY-11Α,9Α-EPOXYMETHANOPROSTAGLANDIN F2Α 9,11-DIDEOXY-11A,9A-EPOXYMETHANO-*PROSTA GLANDIN F2A 9,11-dideoxy-11alpha,9alpha-epoxymethanoprostaglandin F2a 9,11-DIDEOXY-11Α,9Α-EPOXYMETHANOPROSTAGLANDIN F2Α,SOLUTION (5Z)-7-[(1R,4S)-6β-[(1E,3S)-3-Hydroxy-1-octenyl]-2-oxabicyclo[2.2.1]heptan-5α-yl]-5-heptenoic acid (5Z)-7-[(1R,4S,5S,6R)-6-[(1E,3S)-3-Hydroxy-1-octenyl]-2 -oxabicyclo[2.2.1]hept-5-yl]-5-heptenoic acid |
CAS | 56985-40-1 |
化学式 | C21H34O4 |
分子量 | 350.49 |
闪点 | -10°C |
存储条件 | -20°C |
外观 | 溶液 |
BRN | 4267334 |
体外研究 | U-46619 (1 nM-10 μM) causes platelets shape change and aggregation in a concentration-dependent manner, and with EC 50 s of 0.58 μM and 0.013 μM for aggregation and shape change, respectively. U-46619 (10 nM-10 μM) increases internal Ca 2+ concentration ([Ca 2+ ]i) and activates phosphoinositide (PI) hydrolysis in a concentration-dependent manner with a similar concentration-dependency. U-46619 (3 nM-10 μM) also activates GTPase concentration-dependently in the membranes derived from platelets. U-46619 improves the differentiation efficiency of human induced pluripotent stem cells into endothelial cells by activating both p38MAPK and ERK1/2 signaling pathways. |
危险品标志 | F - 易燃物品 Xi - 刺激性物品 |
风险术语 | R11 - 高度易燃。 R36 - 刺激眼睛。 R66 - 长期接触可能引起皮肤干裂。 R67 - 蒸汽可能引起困倦和眩晕。 |
安全术语 | S16 - 远离火源。 S26 - 不慎与眼睛接触后,请立即用大量清水冲洗并征求医生意见。 |
危险品运输编号 | UN 1231 3/PG 2 |
WGK Germany | 2 |
RTECS | MJ9681090 |
FLUKA BRAND F CODES | 8-10-23 |