中文名 | 2'-脱氧肌苷 |
英文名 | 2'-Deoxyinosine |
别名 | 2-脱氧肌苷 2ˊ-脱氧肌苷 2'-脱氧肌苷 2ˊ-脱氧次黄嘌呤核苷 2'-脱氧-肌苷一水合物 2'-脱氧-肌苷 水合物 9-(2-脱氧-Β-D-呋喃核糖)黄嘌呤 9-(2-脱氧-Β-D-呋喃核糖基)次黄嘌呤 9-(2-脱氧-Β-D-呋喃核糖基)次黄嘌呤2'-脱氧次黄嘌呤核苷2'-脱氧肌苷 |
英文别名 | Deoxyinosine 2'-Deoxyinosine Inosine, 2'-deoxy- 2'-Deoxyinosine(Di) DEOXYINOSINE, 2'-(RG) Didanosine EP Impurity C 1,9-Dihydro-9-(2'-deoxy-β-D-ribofuranosyl)-6H-purin-6-one 9-[(2R,4S,5R)-4-hydroxy-5-(hydroxyMethyl)oxolan-2-yl]-9H-purin-6-ol 9-((2R,4S,5R)-4-Hydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol |
CAS | 890-38-0 |
EINECS | 212-964-1 |
化学式 | C10H12N4O4 |
分子量 | 252.23 |
InChI | InChI=1/C10H12N4O4/c15-2-6-5(16)1-7(18-6)14-4-13-8-9(14)11-3-12-10(8)17/h3-7,15-16H,1-2H2,(H,11,12,17)/t5-,6+,7+/m0/s1 |
密度 | 1.3402 (rough estimate) |
熔点 | 250 °C |
沸点 | 395.4°C (rough estimate) |
比旋光度 | 21 º (c=1, H2O 22 ºC) |
闪点 | 365.8°C |
水溶性 | 8.33g/L(25.02 ºC) |
蒸汽压 | 1.72E-19mmHg at 25°C |
溶解度 | DMSO (微溶) 、Waterh (微溶) |
折射率 | -16 ° (C=1, H2O) |
酸度系数 | 8.92±0.70(Predicted) |
存储条件 | -20°C |
外观 | 粉末 |
颜色 | White to Off-white |
BRN | 33517 |
物化性质 | 白色粉末,可溶于甲醇、乙醇、DMSO等有机溶剂。 |
MDL号 | MFCD00005762 |
体外研究 | In the absence of deoxycoformycin, 2’-deoxyadenosine is primarily deaminated to 2’-deoxyinosine and then converted into hypoxanthine. In the presence of the inhibitor, the deoxynucleoside, in addition to a phosphorylation process, undergoes phosphorolytic cleavage giving rise to adenine. The conversion of 2’-deoxyadenosine to adenine might represent a protective device, emerging when the activity of adenosine deaminase is reduced or inhibited. There is much evidence to indicate that the enzyme catalyzing this processs may be distinct from methylthioadenosine phosphorylase and S-adenosyl homocysteine hydrolase, which are the enzymes reported to be responsible for the formation of adenine from 28-deoxyadenosine in mammals. |
危险品标志 | Xn - 有害物品 Xi - 刺激性物品 |
风险术语 | R20/21/22 - 吸入、皮肤接触及吞食有害。 R36/37/38 - 刺激眼睛、呼吸系统和皮肤。 |
安全术语 | S24/25 - 避免与皮肤和眼睛接触。 S37/39 - 戴适当的手套和护目镜或面具。 S36 - 穿戴适当的防护服。 S26 - 不慎与眼睛接触后,请立即用大量清水冲洗并征求医生意见。 |
WGK Germany | 3 |
FLUKA BRAND F CODES | 10-23 |
海关编号 | 29349990 |
参考资料 展开查看 | 1. 肖会敏, 何悦, 雷美娜,等. 地龙胶囊的HPLC特征图谱和10种成分的定量研究[J]. 西北药学杂志, 2018, 033(005):569-574. 2. 何悦, 肖会敏, 康晓刚, et al. 地龙胶囊及其主成分对小鼠移植瘤S_(180)辐射增敏的研究[J]. 西北药学杂志, 2019. 3. [IF=6.529] Yarigui Bao et al."Therapeutic effects of Chinese medicine Di-Long (Pheretima vulgaris) on rheumatoid arthritis through inhibiting NF-κB activation and regulating Th1/Th2 balance."Biomed Pharmacother. 2022 Mar;147:112643 |
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