中文名 | 伊维菌素 B1A |
英文名 | Avermectin A1a, 5-O-demethyl-22,23-dihydro- |
别名 | 依维菌素B1A 伊维菌素杂质1 伊维菌素 B1A |
英文别名 | Ivermectin B1a IvermectinH2B1a Ivermectin Impurity 3 Dihydroavermectin B1a 5-O-Demethyl-22,23-dihydroavermectin A1a 22,23-Dihydro-5-O-demethylavermectin A1a Avermectin A1a, 5-O-demethyl-22,23-dihydro- (2Ae,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17ar,20R,20ar,20bs)-20,20B-dihydroxy-5',6,8,19-tetramethyl-6'-[(1S)-1-methylpropyl]-17-oxo-3',4',5',6,6',10,11,14,15,17,17A,20,20A,20B-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacyclooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-o-(2,6-dideoxy-3-o-methyl-alpha-L-arabino-hexopyranosyl)-3-o-methyl-alpha-L-arabino-hexopyranoside |
CAS | 71827-03-7 |
EINECS | 276-046-2 |
化学式 | C48H74O14 |
分子量 | 875.09 |
密度 | 1.0683 (rough estimate) |
熔点 | 155-157° |
沸点 | 717.97°C (rough estimate) |
折射率 | 1.6130 (estimate) |
酸度系数 | 12.42±0.70(Predicted) |
体外研究 | Ivermectin belongs to the macrocyclic lactone class of avermectins and consists of a mixture of two homologous compounds, ivermectin B1a (not less than 80%) and ivermectin B1b (not more than 20%). Ivermectin B1a, the major component of Ivermectin, is inactive at a concentration of 0.3 μg/ml, whereas in the case of the minor component, ivermectin B1b, the same concentration produces 100% mortality of snails. |
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